Topics

The contribution of ion channels in input-output plasticity.

08:00 EDT 17th September 2019 | BioPortfolio

Summary of "The contribution of ion channels in input-output plasticity."

Persistent changes that occur in brain circuits are classically thought to be mediated by long-term modifications in synaptic efficacy. Yet, many studies have shown that voltage-gated ion channels located at the input and output side of the neurons are also the subject to persistent modifications. These channels are thus responsible for intrinsic plasticity that is expressed in many different neuronal types including glutamatergic principal neurons and GABAergic interneurons. As for synaptic plasticity, activation of synaptic glutamate receptors initiate persistent modification in neuronal excitability. We review here how synaptic input can be efficiently altered by activity-dependent modulation of ion channels that control EPSP amplification, spike threshold or resting membrane potential. We discuss the nature of the learning rules shared by intrinsic and synaptic plasticity, the mechanisms of ion channel regulation and the impact of intrinsic plasticity on induction of synaptic modifications.

Affiliation

Journal Details

This article was published in the following journal.

Name: Neurobiology of learning and memory
ISSN: 1095-9564
Pages: 107095

Links

DeepDyve research library

PubMed Articles [6234 Associated PubMed Articles listed on BioPortfolio]

Why context matters? Divisive normalization and Canonical microcircuits in psychiatric disorders.

Neural activity on cellular, regional, and behavioral levels shows context-dependence. Here we suggest the processing of input-output relationships in terms divisive normalization (DN), including (i) ...

SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces.

Neurons store information by changing synaptic input weights. In addition, they can adjust their membrane excitability to alter spike output. Here, we demonstrate a role of such "intrinsic plasticity"...

Sodium channels implement a molecular leaky integrator that detects action potentials and regulates neuronal firing.

Voltage-gated sodium channels play a critical role in cellular excitability, amplifying small membrane depolarizations into action potentials. Interactions with auxiliary subunits and other factors mo...

Gain Modulation by Corticostriatal and Thalamostriatal Input Signals during Reward-Conditioned Behavior.

The cortex and thalamus send excitatory projections to the striatum, but little is known about how these inputs, either individually or collectively, regulate striatal dynamics during behavior. The la...

Effects of HCN2 mutations on dendritic excitability and synaptic plasticity: A computational study.

Several reports of augmented Hyperpolarisation-activated cyclic nucleotide-gated (HCN) currents in seizures have suggested a pro-convulsive identity for HCN channels. The mutations identified in one o...

Clinical Trials [1799 Associated Clinical Trials listed on BioPortfolio]

CNS Changes Following Stroke

The objective of this study is to better understand the structural and functional changes that the CNS undergoes following stroke and how these changes relate to clinical measures. Both ma...

CNS Changes Following SCI

The objective of this study is to better understand the structural and functional changes that the central nervous system (CNS) undergoes following spinal cord injury and how these changes...

Study of the Reaction of the Brain to Various Stimulations

Physical activity is considered a therapeutic strategy in its own right in a vast majority of disabling chronic disorders. It leads to an increase in physical and probably cognitive capaci...

Evaluation of the Accuracy, Safety and Robustness of a Single-Input-Single-Output (SISO) Model-Based Predictive Closed-Loop System to Guide Patient-Individualized ICU Sedation

The aim of this study is to investigate the accuracy, safety and robustness of a single-input-single output (SISO) model-based predictive closed-loop system to guide patient-individualized...

A Pilot Evaluation of Adhesives and How They Are Impacted by Out-put

The study investigates the impact real output (subjects own) and simulated output have on the adhesion of adhesives.

Medical and Biotech [MESH] Definitions

Input/output devices designed to receive data in an environment associated with the job to be performed, and capable of transmitting entries to, and obtaining output from, the system of which it is a part. (Computer Dictionary, 4th ed.)

Computers whose input, output and state transitions are carried out by biochemical interactions and reactions.

A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.

The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.

A MACHINE LEARNING paradigm used to make predictions about future instances based on a given set of unlabeled paired input-output training (sample) data.

Quick Search


DeepDyve research library

Searches Linking to this Article