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Inhibition of Mitochondrial Complex I Aggravates Folic Acid-Induced Acute Kidney Injury.

08:00 EDT 25th September 2019 | BioPortfolio

Summary of "Inhibition of Mitochondrial Complex I Aggravates Folic Acid-Induced Acute Kidney Injury."

Some researches revealed that mitochondrial dysfunction is associated with various kidney injury. However, the role of mitochondrial dysfunction in the pathogenesis of acute kidney injury (AKI) still needs evidence.

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This article was published in the following journal.

Name: Kidney & blood pressure research
ISSN: 1423-0143
Pages: 1-12

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Medical and Biotech [MESH] Definitions

The active metabolite of FOLIC ACID. Leucovorin is used principally as its calcium salt as an antidote to folic acid antagonists which block the conversion of folic acid to folinic acid.

Cell surface receptors that bind to and transport FOLIC ACID, 5-methyltetrahydrofolate, and a variety of folic acid derivatives. The receptors are essential for normal NEURAL TUBE development and transport folic acid via receptor-mediated endocytosis.

Derivatives of folic acid (pteroylglutamic acid). In gamma-glutamyl linkage they are found in many tissues. They are converted to folic acid by the action of pteroylpolyglutamate hydrolase or synthesized from folic acid by the action of folate polyglutamate synthetase. Synthetic pteroylpolyglutamic acids, which are in alpha-glutamyl linkage, are active in bacterial growth assays.

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Proteins involved in the transport of FOLIC ACID and folate derivatives across the CELLULAR MEMBRANE.

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