Topics

Smelling Danger: Olfactory Stem Cells Control Immune Defense during Chronic Inflammation.

08:00 EDT 3rd October 2019 | BioPortfolio

Summary of "Smelling Danger: Olfactory Stem Cells Control Immune Defense during Chronic Inflammation."

Neurogenesis is critical to continuously replacie olfactory neurons but is impaired during chronic inflammatory rhinosinusitis. In this issue of Cell Stem Cell, Chen et al. (2019) describe the inflammation-induced switching of olfactory stem cells from a regenerative phenotype to one participating in immune defense; this process contributes to deficient replacement of olfactory sensory neurons.

Affiliation

Journal Details

This article was published in the following journal.

Name: Cell stem cell
ISSN: 1875-9777
Pages: 449-451

Links

DeepDyve research library

PubMed Articles [27428 Associated PubMed Articles listed on BioPortfolio]

Potential of breastmilk in stem cell research.

Breastmilk is a dynamic, multi-faceted, and complex fluid containing a plethora of biochemical and cellular components that execute developmental effects or differentiation program, providing nourishm...

Efficiency of human olfactory ensheathing cell transplantation into spinal cysts to improve mobility of the hind limbs.

The pathological processes developing after spinal cord injuries often lead to the formation of cysts. Existing surgical and medical methods are insufficient for the treatment of posttraumatic spinal ...

An IL-2 proaerolysin fusion toxin that selectively eliminates regulatory t cells to enhance antitumor immune response.

Recent success with immune-checkpoint inhibitors in some tumor types has highlighted the power of the immune system to control and eradicate human cancer cells. However, these therapies have demonstr...

Concise Review: Targeting multiple cell surface receptors in tumors with engineered stem cells.

Multiple stem cell types exhibit inherent tropism for cancer, and engineered stem cells have been used as therapeutic agents to specifically target cancer cells. Recently, stem cells have been enginee...

Sensory evaluation of e-liquid flavors by smelling and vaping yields similar results.

Sensory research on e-liquid flavors can be performed by means of smelling and vaping. However, data comparing smelling versus vaping e-liquid flavors is lacking. This study aims to investigate if sme...

Clinical Trials [15219 Associated Clinical Trials listed on BioPortfolio]

Collection and Characterisation of Human Olfactory Ensheathing Cells

To obtain olfactory bulbs from brain stem dead patients who undergo organ donation. Aims: 1. Optimisation of olfactory bulb collection and olfactory ensheathing cell culture and ...

Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells

The trial evaluates the safety and efficacy of the olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis

Danger Signs in Heart Failure- Effects of Video Education

Lack of recognition of HF danger signs and lack of understanding of how to control and minimize danger signs could lead to their escalation and prompt all-cause and HF-related health care ...

Assesment of Olfactory Disorders and Performance of a New Olfactory Test in Children With Congenital CMV

CMV lesions were found in the olfactory system of children with congenital CMV infection but no study has hitherto examined the impact of congenital CMV infection on olfaction. So the inve...

Cytotoxic T-Lymphocytes for the Prophylaxis of Cytomegalovirus After Allogeneic Stem Cell Transplant

Patients enrolled on this study have a type of blood cell cancer, other blood disease or a genetic disease for which they will receive a stem cell transplant. The donor of the stem cells w...

Medical and Biotech [MESH] Definitions

That portion of the nasal mucosa containing the sensory nerve endings for SMELL, located at the dome of each NASAL CAVITY. The yellow-brownish olfactory epithelium consists of OLFACTORY RECEPTOR NEURONS; brush cells; STEM CELLS; and the associated olfactory glands.

Ovoid body resting on the cribriform plate of the ethmoid bone where the olfactory nerve terminates. The olfactory bulb contains several types of nerve cells including the mitral cells, on whose dendrites the olfactory nerve synapses, forming the olfactory glomeruli. The accessory olfactory bulb, which receives the projection from the VOMERONASAL ORGAN via the vomeronasal nerve, is also included here.

Regeneration of normal immune function after immune depleting procedures or infections (e.g., HEMATOPOIETIC STEM CELL TRANSPLANTATION). Delayed and incomplete reconstitution of the ADAPTIVE IMMUNE system in particular involving T-CELLS is associated with increase or relapse of infection.

Set of nerve fibers conducting impulses from olfactory receptors to the cerebral cortex. It includes the OLFACTORY NERVE; OLFACTORY BULB; olfactory tract, olfactory tubercle, anterior perforated substance, and olfactory cortex. The term rhinencephalon is restricted to structures in the CNS receiving fibers from the olfactory bulb.

Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)

Quick Search


DeepDyve research library

Relevant Topic

Stem Cells
Track and monitor developments in stem cell research and commercial development.  Follow the tabs above to read the latest global news, research, clinical trials on stem cells and follow companies active in the stem cell industry.  BioPort...


Searches Linking to this Article