Preterm Physiologically Based Pharmacokinetic Model. Part II: Applications of the Model to Predict Drug Pharmacokinetics in the Preterm Population.
Summary of "Preterm Physiologically Based Pharmacokinetic Model. Part II: Applications of the Model to Predict Drug Pharmacokinetics in the Preterm Population."
Preterm neonates are usually not part of a traditional drug development programme, however they are frequently administered medicines. Developing modelling and simulation tools, such as physiologically based pharmacokinetic (PBPK) models that incorporate developmental physiology and maturation of drug metabolism, can be used to predict drug exposure in this group of patients, and may help to optimize drug dose adjustment.
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Journal Details
This article was published in the following journal.
Name: Clinical pharmacokinetics
ISSN: 1179-1926
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/31587145
- DOI: http://dx.doi.org/10.1007/s40262-019-00827-4
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