Topics

Penetration of Petrolatum in Stratum Corneum from Bodywash Formulation.

07:03 LMT 1st January 0000 | BioPortfolio

Summary of "Penetration of Petrolatum in Stratum Corneum from Bodywash Formulation."

Petrolatum is a mixture of hydrocarbons that is widely used as a moisturizer. It is incorporated in bodywash formulations to help hydrate and maintain healthy skin appearance. The aim of this study was to investigate skin deposition and penetration of petrolatum from an experimental bodywash system consisting of petrolatum . Experiments were performed using cadaver split-thickness skin and Franz diffusion cells. Radiolabeled C-dotriacontane (C-alkane) was used as a model permeant for petrolatum. The bodywash was applied on the skin and subsequently rinsed. At predetermined time points, the skin was wiped to remove the residual material on the surface, and tape-stripping was performed. Petrolatum was observed to deposit from the bodywash when applied on split-thickness skin with simulated rinsing. Petrolatum then penetrated into the stratum corneum and was detected at the depth of 12 tape-stripping and in the epidermis. The bodywash formulation could provide significant deposition and penetration of petrolatum into the stratum corneum at 1-72 hours postapplication.

Affiliation

Journal Details

This article was published in the following journal.

Name: Journal of cosmetic science
ISSN: 1525-7886
Pages: 247-257

Links

DeepDyve research library

PubMed Articles [1638 Associated PubMed Articles listed on BioPortfolio]

Combined effects of glycerol and petrolatum in an emollient cream: A randomized, double-blind, crossover study in healthy volunteers with dry skin.

The stratum corneum plays an important protective physiological role in providing a barrier to preventing skin desiccation and penetration of external agents. Emollients are used commonly to improve b...

Noninvasive Determination of Epidermal and Stratum Corneum Thickness in vivo Using Two-Photon Microscopy and Optical Coherence Tomography: Impact of Body Area, Age, and Gender.

High-resolution images of the epidermis are important to understand the transdermal penetration and changes in epidermal components. Both ex vivo and in vivo technologies are available to picture the ...

Amino acids disrupt calcium-dependent adhesion of stratum corneum.

In the stratum corneum, the intercellular junction made up of cadherin proteins provides the structural integrity of the framework. Ca2+ ions are known to play a key role in maintaining this junction....

The role of vehicle metamorphosis on triamcinolone acetonide delivery to the skin from microemulsions.

After application to the skin surface, a topical formulation is submitted to changes in composition produced by evaporation of volatile components, penetration of components into the skin and extracti...

Skin Metabolism: Relevance of Skin Enzymes for Rational Drug Design.

Transdermal therapeutic systems (TTS) have numerous pharmacological benefits. Drug release, for example, is independent of whether a patient is in a fed or a fasted state, and lower doses can be given...

Clinical Trials [1778 Associated Clinical Trials listed on BioPortfolio]

Formulation and Clinical Evaluation of Ethosomal and Liposomal Preparations of Anthralin in Psoriasis

Psoriasis is a common immune mediated inflammatory skin disease characterized by red heavily scaled plaques. Anthralin (1,8-dihydroxy-9-anthrone) which was introduced over 80 years ago has...

Dermatopharmacokinetic Trial of LEO 80185 Gel

Given that LEO 80185 gel takes effect in the upper layer of the skin, it is important to compare and examine the amount of the drug in the upper layer of the skin with that of Dovobet® Oi...

Transcriptomic Study of ER 4017 Topical Application in Elderly Subject

The stratum corneum (SC) is the superficial layer of the epidermis situated at the interface between the body and its outside environment. Its strategic position confers it a crucial role ...

Evaluation of Skin Irritation Potential With PF-06700841 Cream Formulation Using Negative Control in Adult Japanese Healthy Participants

This is a Phase 1, single center, randomized, vehicle and white petrolatum controlled, evaluator blinded study to assess the skin irritation potential with a range of concentrations of PF-...

Wound Dressings for Pemphigus and Pemphigoid

The purpose of this study is to compare the efficacy of four dressings (covers) namely: gauze with petrolatum , cellulose acetate with petrolatum , pure carboxymethylcellulose with silver...

Medical and Biotech [MESH] Definitions

The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).

Persistence of the nuclei of the keratinocytes into the stratum corneum of the skin. This is a normal state only in the epithelium of true mucous membranes in the mouth and vagina. (Dorland, 27th ed)

Group of mostly hereditary disorders characterized by thickening of the palms and soles as a result of excessive keratin formation leading to hypertrophy of the stratum corneum (hyperkeratosis).

Any of several generalized skin disorders characterized by dryness, roughness, and scaliness, due to hypertrophy of the stratum corneum epidermis. Most are genetic, but some are acquired, developing in association with other systemic disease or genetic syndrome.

Tough, horny, brittle, smooth, striated or plate-like extensions of the stratum corneum or outer layer of the skin. It serves as a protective layer in fishes, reptiles, birds, and mammals.

Quick Search
DeepDyve research library

Relevant Topics

Dermatology
Acne Dermatology Eczema Psoriasis Wound Care Dermatology is the medical specialty concerned with the diagnosis and treatment of skin disorders (Oxford Medical Dictionary). As well as studying how the skin works, dermatology covers...

Wound management
Anything that breaks the skin is a wound because when the skin is broken, there's a risk of germs getting into the body and causing an infection. Follow and track Wound Care News on BioPortfolio: Wound Car...


Searches Linking to this Article