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Petrolatum is a mixture of hydrocarbons that is widely used as a moisturizer. It is incorporated in bodywash formulations to help hydrate and maintain healthy skin appearance. The aim of this study was to investigate skin deposition and penetration of petrolatum from an experimental bodywash system consisting of petrolatum . Experiments were performed using cadaver split-thickness skin and Franz diffusion cells. Radiolabeled C-dotriacontane (C-alkane) was used as a model permeant for petrolatum. The bodywash was applied on the skin and subsequently rinsed. At predetermined time points, the skin was wiped to remove the residual material on the surface, and tape-stripping was performed. Petrolatum was observed to deposit from the bodywash when applied on split-thickness skin with simulated rinsing. Petrolatum then penetrated into the stratum corneum and was detected at the depth of 12 tape-stripping and in the epidermis. The bodywash formulation could provide significant deposition and penetration of petrolatum into the stratum corneum at 1-72 hours postapplication.
This article was published in the following journal.
Name: Journal of cosmetic science
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The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).
Persistence of the nuclei of the keratinocytes into the stratum corneum of the skin. This is a normal state only in the epithelium of true mucous membranes in the mouth and vagina. (Dorland, 27th ed)
Group of mostly hereditary disorders characterized by thickening of the palms and soles as a result of excessive keratin formation leading to hypertrophy of the stratum corneum (hyperkeratosis).
Any of several generalized skin disorders characterized by dryness, roughness, and scaliness, due to hypertrophy of the stratum corneum epidermis. Most are genetic, but some are acquired, developing in association with other systemic disease or genetic syndrome.
Tough, horny, brittle, smooth, striated or plate-like extensions of the stratum corneum or outer layer of the skin. It serves as a protective layer in fishes, reptiles, birds, and mammals.
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