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Interrater reliability of a method to assess hypothalamic involvement in pediatric adamantinomatous craniopharyngioma.

08:00 EDT 11th October 2019 | BioPortfolio

Summary of "Interrater reliability of a method to assess hypothalamic involvement in pediatric adamantinomatous craniopharyngioma."

Pediatric adamantinomatous craniopharyngiomas (ACPs) are histologically benign brain tumors that confer significant neuroendocrine morbidity. Previous studies have demonstrated that injury to the hypothalamus is associated with worsened quality of life and a shorter lifespan. This insight helps many surgeons define the goals of surgery for patients with ACP. Puget and colleagues proposed a 3-tiered preoperative and postoperative grading system based on the degree of hypothalamic involvement identified on MRI. In a prospective cohort from their institution, the authors found that use of the system to guide operative goals was associated with decreased morbidity. To date, however, the Puget system has not been externally validated. Here, the authors present an interrater reliability study that assesses the generalizability of this system for surgeons planning initial operative intervention for children with craniopharyngiomas.

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This article was published in the following journal.

Name: Journal of neurosurgery. Pediatrics
ISSN: 1933-0715
Pages: 1-6

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