Topics

REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories.

08:00 EDT 20th September 2019 | BioPortfolio

Summary of "REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories."

The neural mechanisms underlying memory regulation during sleep are not yet fully understood. We found that melanin concentrating hormone-producing neurons (MCH neurons) in the hypothalamus actively contribute to forgetting in rapid eye movement (REM) sleep. Hypothalamic MCH neurons densely innervated the dorsal hippocampus. Activation or inhibition of MCH neurons impaired or improved hippocampus-dependent memory, respectively. Activation of MCH nerve terminals in vitro reduced firing of hippocampal pyramidal neurons by increasing inhibitory inputs. Wake- and REM sleep-active MCH neurons were distinct populations that were randomly distributed in the hypothalamus. REM sleep state-dependent inhibition of MCH neurons impaired hippocampus-dependent memory without affecting sleep architecture or quality. REM sleep-active MCH neurons in the hypothalamus are thus involved in active forgetting in the hippocampus.

Affiliation

Journal Details

This article was published in the following journal.

Name: Science (New York, N.Y.)
ISSN: 1095-9203
Pages: 1308-1313

Links

DeepDyve research library

PubMed Articles [17928 Associated PubMed Articles listed on BioPortfolio]

Forgetting at biologically realistic levels of neurogenesis in alarge-scale hippocampal model.

Neurogenesis persists throughout life in the dentate gyrus region of the mammalian hippocampus. Computational models have established that the addition of neurons degrades existing memories (i.e., pro...

Opposite Effect of Motivated Forgetting on Sleep Spindles during Stage 2 and Slow Wave Sleep.

Memories selectively benefit from sleep. In addition to the importance of the consolidation of relevant memories, the capacity to forget unwanted memories is also crucial. We investigated the effect o...

Sleep and the Balance between Memory and Forgetting.

Slow oscillations and delta waves are neuronal activity rhythms that hallmark sleep, but until now their respective functional roles have been impossible to tease apart. Utilizing a closed-loop optoge...

Competing Roles of Slow Oscillations and Delta Waves in Memory Consolidation versus Forgetting.

Sleep has been implicated in both memory consolidation and forgetting of experiences. However, it is unclear what governs the balance between consolidation and forgetting. Here, we tested how activity...

The hippocampus is necessary for the consolidation of a task that does not require the hippocampus for initial learning.

During sleep, the hippocampus plays an active role in consolidating memories that depend on it for initial encoding. There are hints in the literature that the hippocampus may have a broader influence...

Clinical Trials [9054 Associated Clinical Trials listed on BioPortfolio]

Cerebral Prophylactic Irradiation With Saving Hippocampus and Amygdala

Hippocampus and amygdala are parts of the brain involved in the recognition of emotions, memories, memory, language ... It is therefore very important to protect them during irradiation of...

Measured Hypocretin Levels and Recovery After Hip Surgery

A specific group of neurons in the brain produces hypocretin, a peptide which has been established as an important regulator of sleep and wakefulness. Activation of these neurons (increase...

Sleep and Wellbeing Study

Most people will experience a psychologically traumatic event, such as a life-threatening accident, at some point in their life. In the initial days after such an event, it is common to be...

The Evolution of Memories Across Wake and Sleep

To further understanding of the relationship between sleep and memory the investigators will address and attempt to answer three questions, (1) how memories evolve across wake and sleep, (...

Mindful Attention to Variability in Everyday Memory

Forgetfulness is a common complaint among middle and older adults, with the vast majority of these complaints not rooted in established causes or diagnoses. The contents of these subjectiv...

Medical and Biotech [MESH] Definitions

Periods of sleep manifested by changes in EEG activity and certain behavioral correlates; includes Stage 1: sleep onset, drowsy sleep; Stage 2: light sleep; Stages 3 and 4: delta sleep, light sleep, deep sleep, telencephalic sleep.

Dyssomnias (i.e., insomnias or hypersomnias) associated with dysfunction of internal sleep mechanisms or secondary to a sleep-related medical disorder (e.g., sleep apnea, post-traumatic sleep disorders, etc.). (From Thorpy, Sleep Disorders Medicine, 1994, p187)

Movements or behaviors associated with sleep, sleep stages, or partial arousals from sleep that may impair sleep maintenance. Parasomnias are generally divided into four groups: arousal disorders, sleep-wake transition disorders, parasomnias of REM sleep, and nonspecific parasomnias. (From Thorpy, Sleep Disorders Medicine, 1994, p191)

A nonapeptide that is found in neurons, peripheral organs, and plasma. This neuropeptide induces mainly delta sleep in mammals. In addition to sleep, the peptide has been observed to affect electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs including their withdrawal.

Gray matter situated above the gyrus hippocampi. It is composed of three layers. The molecular layer is continuous with the HIPPOCAMPUS in the hippocampal fissure. The granular layer consists of closely arranged spherical or oval neurons, called granule cells, whose AXONS pass through the polymorphic layer ending on the DENDRITES of pyramidal cells in the hippocampus.

Quick Search


DeepDyve research library

Relevant Topics

Sleep Disorders
Sleep disorders disrupt sleep during the night, or cause sleepiness during the day, caused by physiological or psychological factors. The common ones include snoring and sleep apnea, insomnia, parasomnias, sleep paralysis, restless legs syndrome, circa...

Endocrinology
Diabetes Diabetes Endocrine Disorders Obesity Oxycontin Renal Disease Thyroid Disorders Endocrinology is the study of the endocrine glands and the hormones that they secrete (Oxford Medical Dictionary). There are several g...


Searches Linking to this Article