A Retrospective Chart Review on Oral Retinoids as a Treatment for Epidermal Growth Factor Receptor Inhibitor and Mitogen-activated Protein Kinase Kinase Inhibitor Induced Acneiform Eruptions.

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Summary of "A Retrospective Chart Review on Oral Retinoids as a Treatment for Epidermal Growth Factor Receptor Inhibitor and Mitogen-activated Protein Kinase Kinase Inhibitor Induced Acneiform Eruptions."

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Name: Journal of the American Academy of Dermatology
ISSN: 1097-6787


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A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. EPIDERMAL GROWTH FACTOR exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and epithelial cells.

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The concurrent or retrospective review by practicing physicians or other health professionals of the quality and efficiency of patient care practices or services ordered or performed by other physicians or other health professionals (From The Facts On File Dictionary of Health Care Management, 1988).

A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF related peptides including TRANSFORMING GROWTH FACTOR ALPHA, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.

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