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Part I. Hidradenitis Suppurativa: Epidemiology, clinical presentation, and pathogenesis.

08:00 EDT 8th October 2019 | BioPortfolio

Summary of "Part I. Hidradenitis Suppurativa: Epidemiology, clinical presentation, and pathogenesis."

Hidradenitis suppurativa (HS) is an inflammatory disorder characterized by chronic deep-seated nodules, abscesses, fistulae, sinus tracts and scars in the axilla, inguinal area, sub-mammary folds and perianal area. This disfiguring condition is accompanied by pain, embarrassment and a significantly decreased quality of life. Although the mechanism of HS has not been entirely elucidated, lesion formation is believed to center around follicular hyperkeratosis within the pilosebaceous-apocrine unit. Recent research has provided new insight into the role of cytokines in the pathogenesis of HS, helping to close some existing knowledge gaps in the development of this condition. The first article in this continuing medical education series reviews HS epidemiology, clinical presentation, and classification. We also provide an update on the most recent understanding of HS pathogenesis, including the central role of inflammatory cytokines as well as other contributing factors such as genetics, hormones, and pathogenic microorganisms.

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This article was published in the following journal.

Name: Journal of the American Academy of Dermatology
ISSN: 1097-6787
Pages:

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PubMed Articles [27111 Associated PubMed Articles listed on BioPortfolio]

A gene dysfunction module reveals the underlying pathogenesis of hidradenitis suppurativa: An update.

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Studying Complement Inhibition in Patients With Moderate to Severe Hidradenitis Suppurativa

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Medical and Biotech [MESH] Definitions

A chronic suppurative and cicatricial disease of the apocrine glands occurring chiefly in the axillae in women and in the groin and anal regions in men. It is characterized by poral occlusion with secondary bacterial infection, evolving into abscesses which eventually rupture. As the disease becomes chronic, ulcers appear, sinus tracts enlarge, fistulas develop, and fibrosis and scarring become evident.

The inflammation of a sweat gland (usually of the apocrine type). The condition can be idiopathic or occur as a result of or in association with another underlying condition. Neutrophilic eccrine hidradenitis is a relatively rare variant that has been reported in patients undergoing chemotherapy, usually for non-Hodgkin lymphomas or leukemic conditions.

Investigative techniques used in pre-clinical and clinical research, epidemiology, chemistry, immunology, genetics, etc. They do not include techniques specifically applied to DIAGNOSIS; THERAPEUTICS; anesthesia and analgesia; SURGICAL PROCEDURES, OPERATIVE; and DENTISTRY.

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Infiltration of inflammatory cells into the parenchyma of PROSTATE. The subtypes are classified by their varied laboratory analysis, clinical presentation and response to treatment.

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