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Part 2. Current and emerging treatments for hidradenitis suppurativa.

08:00 EDT 8th October 2019 | BioPortfolio

Summary of "Part 2. Current and emerging treatments for hidradenitis suppurativa."

Treatment of hidradenitis suppurativa (HS) has remained challenging due to the many knowledge gaps regarding etiology. However, recent studies into the pathogenesis of HS have enabled the investigation of newer therapies. The second article in this continuing medical education series reviews the evidence for established therapies for HS, including anti-inflammatories, antibiotics, and surgery. New and emerging therapies that specifically target cytokines involved in HS pathogenesis will be covered. The potential therapeutic roles of anti-cytokine therapies, including both the expanded application of existing molecules as well as the specific development of novel therapies for HS are discussed. With increased attention on HS and with numerous clinical trials currently underway the variety of treatment options for HS hopefully will be expanded.

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This article was published in the following journal.

Name: Journal of the American Academy of Dermatology
ISSN: 1097-6787
Pages:

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PubMed Articles [17813 Associated PubMed Articles listed on BioPortfolio]

A gene dysfunction module reveals the underlying pathogenesis of hidradenitis suppurativa: An update.

Hidradenitis suppurativa is a chronic skin disease characterised by repeated skin abscesses with sinus tracts and scar formation. Currently, the aetiology and pathogenesis of hidradenitis suppurativa ...

Hidradenitis suppurativa and polycystic ovarian syndrome: Systematic review and meta-analysis.

Hidradenitis suppurativa has been associated with a number of pathologies, including various endocrine and autoimmune disorders. Although signs of hyperandrogenism are common in hidradenitis suppurati...

Associations of cutaneous and extra-cutaneous infections with Hidradenitis Suppurativa in US children and adults.

Hidradenitis suppurativa (HS) is associated with bacterial colonization, skin-barrier disruption, immune dysregulation, and treatments that can increase infection risk.

A qualitative analysis of psychological distress in Hidradenitis Suppurativa.

Hidradenitis Suppurativa (HS) can negatively impact on patients' quality of life (QoL) and is associated with a higher risk of depression, as well as difficulties in employment and relationships OBJEC...

Clinical manifestations and quality of life in hidradenitis suppurativa patients: survey of participants from an internet support group.

Hidradenitis suppurativa is a complex and infrequent autoinflammatory disease that impacts on quality of life. Its pathogenesis is not fully understood, which limits the development of curative treatm...

Clinical Trials [5329 Associated Clinical Trials listed on BioPortfolio]

Studying Complement Inhibition in Patients With Moderate to Severe Hidradenitis Suppurativa

The trial enrolls patients with moderate to severe Hidradenitis Suppurativa (HS). The primary goal of the trial is to evaluate the safety and tolerability of IFX-1 administered over 8 week...

Post-Marketing Surveillance of Adalimumab in Korean Hidradenitis Suppurativa Subjects

The objective of this study is to evaluate the safety profile of Adalimumab for Hidradenitis Suppurativa (HS) participants in normal medical practice.

A Randomized Controlled Trial Evaluating the Efficacy of Intralesional Triamcinolone in Hidradenitis Suppurativa.

Purpose: To evaluate the effectiveness of intralesional triamcinolone for the treatment of hidradenitis suppurativa Participants: Patients diagnosed with Hidradenitis Suppurativa that hav...

Study of Adalimumab in Subjects With Moderate to Severe Chronic Hidradenitis Suppurativa

This study will investigate how well adalimumab works in people with hidradenitis suppurativa (HS) in the short and long term.

Single Center Study of Apremilast for the Treatment of Hidradenitis Suppurativa

The primary objective of this study is to evaluate the safety and efficacy of Apremilast in subjects with moderate hidradenitis suppurativa (HS).

Medical and Biotech [MESH] Definitions

A chronic suppurative and cicatricial disease of the apocrine glands occurring chiefly in the axillae in women and in the groin and anal regions in men. It is characterized by poral occlusion with secondary bacterial infection, evolving into abscesses which eventually rupture. As the disease becomes chronic, ulcers appear, sinus tracts enlarge, fistulas develop, and fibrosis and scarring become evident.

The inflammation of a sweat gland (usually of the apocrine type). The condition can be idiopathic or occur as a result of or in association with another underlying condition. Neutrophilic eccrine hidradenitis is a relatively rare variant that has been reported in patients undergoing chemotherapy, usually for non-Hodgkin lymphomas or leukemic conditions.

Treatments which are undergoing clinical trials or for which there is insufficient evidence to determine their effects on health outcomes; coverage for such treatments is often denied by health insurers.

Therapeutic introduction of ions of soluble salts into tissues by means of electric current. In medical literature it is commonly used to indicate the process of increasing the penetration of drugs into surface tissues by the application of electric current. It has nothing to do with ION EXCHANGE; AIR IONIZATION nor PHONOPHORESIS, none of which requires current.

Application of electric current in treatment without the generation of perceptible heat. It includes electric stimulation of nerves or muscles, passage of current into the body, or use of interrupted current of low intensity to raise the threshold of the skin to pain.

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