Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and its receptors in Mus musculus testis.

08:00 EDT 8th October 2019 | BioPortfolio

Summary of "Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and its receptors in Mus musculus testis."

To enlighten the involvement of PACAP/receptors system in the control of mammal testis, we investigated the expression of PACAP and the localization of PACAP and its receptors PAC1, VPAC1, and VPAC2 in the testis of Mus musculus. By molecular and immunohistochemical investigations, we highlighted that PACAP and its receptors are widely represented in germ cells of Mus testis, particularly in spermatocytes I, spermatids, and spermatozoa, strongly suggesting their involvement in spermatogenesis process. Moreover, for the first time in the adult mouse testis we highlighted that PACAP is present within Leydig cells, as PACAP receptors, confirming its involvement in the control of steroidogenesis in mouse.


Journal Details

This article was published in the following journal.

Name: General and comparative endocrinology
ISSN: 1095-6840
Pages: 113297


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Medical and Biotech [MESH] Definitions

A pituitary adenylate cyclase-activating peptide receptor subtype that is found in the HYPOTHALAMUS; BRAIN STEM; PITUITARY GLAND; ADRENAL GLAND; PANCREAS; and TESTES and has a high affinity only for PACAP.

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A pituitary adenylate cyclase-activating polypeptide receptor subtype that binds both PACAP and VASOACTIVE INTESTINAL PEPTIDE. It is found predominately in the BRAIN.

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