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How and when to use clozapine.

08:00 EDT 11th October 2019 | BioPortfolio

Summary of "How and when to use clozapine."

Clozapine is the only approved strategy for treatment resistant schizophrenia, although it is highly under-utilized. We aim to generate practical and actionable evidence-based recommendations for the use of this drug considering prescription barriers.

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This article was published in the following journal.

Name: Acta psychiatrica Scandinavica
ISSN: 1600-0447
Pages:

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Medical and Biotech [MESH] Definitions

A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

A subtype of dopamine D2 receptors that has high affinity for the antipsychotic CLOZAPINE.

An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283)

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