Oscillation expression of NF-κB driven by transcription and translation time delays.

08:00 EDT 8th October 2019 | BioPortfolio

Summary of "Oscillation expression of NF-κB driven by transcription and translation time delays."

Oscillation expression of NF-κB signaling system can lead to nuclear NF-κB accumulation which involving various important cellular processes including immune response, inflammation and cancer development. Negative feedback circuits involved in NF-κB signaling system are generally believed to be responsible for the oscillation expression. In view of feedback loops involving time delays resulting from transcription, transcript splicing and processing, and protein synthesis, in this paper, a mathematical model with time delay to describe the core negative feedback circuits centered on NF-κB including IκBα and A20-like proteins is developed. Here, the time delay refer to the time demand of transcription and translation process of IκBα. First, the results suggest that time delay can drive oscillation dynamics of NF-κB signaling system. Concretely, there exists a critical value of time delay. When the time delay exceeds the critical value, the system exhibits oscillation dynamics, and with the increase of time delay, the amplitude and period increase accordingly. Second, analysis indicate that A20-like proteins are able to change the amplitude and period of the nuclear NF-κB oscillations. In addition, the effects of several important parameters on the nuclear NF-κB oscillations are also discussed. Finally, a prediction is formed, which is shortening time delay, repairing and maintaining the function of A20-like proteins, and increasing IκBα transcription rate may be new clues to related disease treatment.


Journal Details

This article was published in the following journal.

Name: IEEE transactions on nanobioscience
ISSN: 1558-2639


DeepDyve research library

PubMed Articles [23987 Associated PubMed Articles listed on BioPortfolio]

Oscillatory dynamics of p53 genetic network induced by feedback loops and time delays.

DNA damage caused by γ-irradiation initiates oscillatory expression of p53 genetic network. Although many studies revealed the effects of p53-Mdm2 circuit on p53 dynamics, few studies explored the co...

Autonomous movement system induced by synergy between pH oscillation and pH responsive oil droplet.

A sustainable droplet motion that is driven by pH oscillation was obtained. The pH oscillation is only of a single pulse in a batch reactor. However, it shows continuous oscillation around the moving ...

Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas.

MYC-driven lymphomas, especially those with concurrent MYC and BCL2 dysregulation, are currently a challenge in clinical practice due to rapid disease progression, resistance to standard chemotherapy,...

Stabilization of Nonautonomous Recurrent Neural Networks With Bounded and Unbounded Delays on Time Scales.

A class of nonautonomous recurrent neural networks (NRNNs) with time-varying delays is considered on time scales. Bounded delays and unbounded delays have been taken into consideration, respectively. ...

SOX2-Dependent Transcription in Clock Neurons Promotes the Robustness of the Central Circadian Pacemaker.

Clock neurons within the mammalian suprachiasmatic nuclei (SCN) encode circadian time using interlocked transcription-translation feedback loops (TTFLs) that drive rhythmic gene expression. However, t...

Clinical Trials [4758 Associated Clinical Trials listed on BioPortfolio]

Minimizing Peri-operative Time Delays, Maximizing Operating Room Efficiency: A Pilot Study

The primary objective is to prospectively identify Operating Room (OR) time delays from the time the patient who is undergoing total laparoscopic hysterectomy enters the OR to exiting the ...

Effects of Physical Activities on the Expression of Nrf2 and Nf-kb Hemodialysis Patients

Oxidative stress and inflammation are cardiovascular risk factors in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). Nuclear transcription factors play roles in th...

Effect of Deep Oscillation Treatment as a Method for Recovery in Soccer

The purpose of this study is to evaluate the effects of Deep Oscillation (DO) self-treatment on recovery after fatiguing soccer training. We investigate deep oscillation (DO) self treatmen...

Time-course of Mitochondrial Biogenic Gene and Protein Expression in Exercised Human Skeletal Muscle

This study examines the impact of exercise intensity on the 12-hour time-course of mitochondrial biogenic gene and protein expression in human skeletal muscle. Briefly, participants will p...

TK216 in Patients With Relapsed or Refractory Ewing Sarcoma

Ewing sarcoma is characterized by genomic rearrangements resulting in over-expression of ets family transcription factors driving tumor progression. TK216 is designed to inhibit this effec...

Medical and Biotech [MESH] Definitions

Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. tat stands for trans-activation of transcription.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.

Insulin formulation containing substance which delays or retards time period of the absorption of insulin.

Quick Search

DeepDyve research library

Relevant Topics

  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...

Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Searches Linking to this Article