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Oscillation expression of NF-κB signaling system can lead to nuclear NF-κB accumulation which involving various important cellular processes including immune response, inflammation and cancer development. Negative feedback circuits involved in NF-κB signaling system are generally believed to be responsible for the oscillation expression. In view of feedback loops involving time delays resulting from transcription, transcript splicing and processing, and protein synthesis, in this paper, a mathematical model with time delay to describe the core negative feedback circuits centered on NF-κB including IκBα and A20-like proteins is developed. Here, the time delay refer to the time demand of transcription and translation process of IκBα. First, the results suggest that time delay can drive oscillation dynamics of NF-κB signaling system. Concretely, there exists a critical value of time delay. When the time delay exceeds the critical value, the system exhibits oscillation dynamics, and with the increase of time delay, the amplitude and period increase accordingly. Second, analysis indicate that A20-like proteins are able to change the amplitude and period of the nuclear NF-κB oscillations. In addition, the effects of several important parameters on the nuclear NF-κB oscillations are also discussed. Finally, a prediction is formed, which is shortening time delay, repairing and maintaining the function of A20-like proteins, and increasing IκBα transcription rate may be new clues to related disease treatment.
This article was published in the following journal.
Name: IEEE transactions on nanobioscience
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Trans-acting transcription factors produced by retroviruses such as HIV. They are nuclear proteins whose expression is required for viral replication. The tat protein stimulates LONG TERMINAL REPEAT-driven RNA synthesis for both viral regulatory and viral structural proteins. tat stands for trans-activation of transcription.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.
Insulin formulation containing substance which delays or retards time period of the absorption of insulin.
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