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Asymmetric Synthesis of the Tricyclooctane Core of Trachylobane Natural Products and Related Terpenoids.

08:00 EDT 11th October 2019 | BioPortfolio

Summary of "Asymmetric Synthesis of the Tricyclooctane Core of Trachylobane Natural Products and Related Terpenoids."

Enantioselective synthesis of a highly versatile building block en route to trachylobanes and related terpenoids is presented. The synthesis features diastereoselective Diels-Alder cycloaddition reaction, a cyclopropanation/homoquadricyclane rearrangement cascade, and palladium-catalyzed C-H acetoxylation. The targeted tricyclooctane was obtained in 20% yield over 8 steps and in 95% ee. The ketone and alcohol functional groups serve as handles for further elaboration.

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Name: Organic letters
ISSN: 1523-7052
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