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Interaction pathways and structure-chemical transformations of alginate gels in physiological environments.

08:00 EDT 11th October 2019 | BioPortfolio

Summary of "Interaction pathways and structure-chemical transformations of alginate gels in physiological environments."

The remarkably diverse affinity of alginate (ALG) macromolecules for polyvalent metal ions makes crosslinked alginate gels an outstanding biomaterial. Surprisingly, however, very little is known about their interactions and structural transformations in physiological environments. To bridge this gap we prepared a set of ALG gels crosslinked by various ions and monitored their structural changes at different media simulating gastric and intestinal fluids and cellular environments. For these studies, we used multinuclear solid-state NMR (ss-NMR) spectroscopy, which revealed a range of competitive ion-exchange and interconversion reactions, the rate of which strongly depended on the nature of the crosslinking metal ions. Depending on the environment, ALG chains adopted different forms, such as acidic (hydro)gels stabilized by strong hydrogen bonds, and/or weakly crosslinked Na/H-gels. Simultaneously the exchanged polyvalent ions extensively interacted with the environment even forming in some cases insoluble phosphate microdomains directly deposited in the ALG bead matrix. The extent of the transformations and incorporation of secondary phases into the alginate beads followed the size and electronegativity of the crosslinking ions. Overall, the applied combination of various macroscopic and biological tests with multinuclear ss-NMR revealed a complex pathway of alginate beads transformations in physiological environments.

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This article was published in the following journal.

Name: Biomacromolecules
ISSN: 1526-4602
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