Topics

Combined SERS Emissions for High-throughput Optical Labels on Micron-scale Objects.

08:00 EDT 11th October 2019 | BioPortfolio

Summary of "Combined SERS Emissions for High-throughput Optical Labels on Micron-scale Objects."

High-throughput optical labeling technologies have become increasingly important with the growing demands for molecular detection, disease diagnosis, and drug discovery. In this thought, a series of CN-bridged coordination polymer encapsulated gold nanoparticles have been developed as a universal and interference-free optical label through a facile and auxiliary agent-free self-assembly route. Moreover, surface-enhanced Raman scattering (SERS) emissions of CN-bridge can be tuned flexibly by simple replacement of Fe2+/Fe3+ with other metal ions relying on synthesis of three Prussian blue analogues encapsulated gold nanoparticles (Au@PBA NPs). Thus, three distinct distinct Raman frequencies have been acquired, merely replaed the metal irons. Based on the potential super-multiplex optical label, space-confined surface-enhanced Raman scattering (SERS) emissions has been realized. Relying on 'Abbe theorem', the focused laser allows the pure and single triple bond-coded SERS emissions being combined into a unique and independent output, so called 'combined SERS emission' (c-SERS), if the Au@PBA NPs were confined into one micron-scale object. This study demonstrated c-SERS may simultaneously provide 2n-1 optical labels only using n single emissions in Raman-silent region for micron-size objects.

Affiliation

Journal Details

This article was published in the following journal.

Name: Analytical chemistry
ISSN: 1520-6882
Pages:

Links

DeepDyve research library

PubMed Articles [17085 Associated PubMed Articles listed on BioPortfolio]

One immunoassay probe makes SERS and fluorescence two readout signals: Rapid imaging and determination of intracellular glutathione levels.

In this paper, one probe (TPPA-VCh) with fluorescence and Surface-enhanced Raman Scattering (SERS) two readout signals, which has high sensitivity and specificity to glutathione in both vitro and cell...

A Sensitive and Simple Competitive Biomimetic Nanozyme-Linked Immunosorbent Assay for Colorimetric and SERS Sensing of Triazophos.

Biomimetic enzyme-linked immunosorbent assay (BELISA) is widely used for detection of small molecule compounds due to low cost and reagent stability of molecularly imprinted polymers (MIPs). However, ...

RI-Insensitive Nanolaminated SERS Substrates for Label-free Raman Profiling and Classification of Living Cancer Cells.

Surface-enhanced Raman spectroscopy (SERS) has emerged as an ultrasensitive molecular fingerprint-based technique for label-free biochemical analysis of biological systems. However, for conventional S...

Nanowire Assisted Repeatable DEP-SERS Detection in Microfluidics.

Surface enhanced Raman spectroscopy (SERS) detection in microfluidics is an interesting topic for its high sensitivity, miniaturization and online detection. In this work, a SERS detection in microflu...

Noninvasive, in vivo rodent brain optical coherence tomography at 2.1  microns.

In biological tissue, longer near-infrared wavelengths generally experience less scattering and more water absorption. Here we demonstrate an optical coherence tomography (OCT) system centered at 2.1...

Clinical Trials [5904 Associated Clinical Trials listed on BioPortfolio]

The Effect of Menu Labels on Calories Ordered in Hispanics

Most studies on menu labels have been conducted in mostly non-Hispanic white individuals, and how menu labels affect calories and macronutrients ordered in Hispanics is not clearly underst...

Testing the Influence of Different Sugary Drink Warning Label Designs

The aim of this study is to compare different sugary drink labels to see which most influence knowledge, beliefs, purchase intentions and choices. Parents of children ages 6-11 will shop i...

High Throughput Drug Sensitivity and Genomics Data in Developing Individualized Treatment in Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell Leukemia

This pilot clinical trial studies whether using high throughput drug sensitivity and genomics data is feasible in developing individualized treatment in patients with multiple myeloma or p...

A Randomized-controlled Experiment of Sugary Drink Warning Labels

The primary objective of this study is to determine to what degree sugary drink warning labels increase consumers' knowledge about the potential health harms of sugary drinks and reduce su...

Clinical Usefulness of Optical Skin Biopsy

Traditional biopsy requires the removal, fixation, and staining of tissues from the human body. Its procedure is invasive and painful. Non-invasive in vivo optical biopsy is thus required,...

Medical and Biotech [MESH] Definitions

Microscopic imaging techniques that utilize nonlinear responses of light-matter interactions which occur with high-intensity illumination, such as from LASERS, and specialized light signal detection instrumentation to produce images without the need for dyes or fluorescent labels.

The use of light interaction (scattering, absorption, and fluorescence) with biological tissue to obtain morphologically based information. It includes measuring inherent tissue optical properties such as scattering, absorption, and autofluorescence; or optical properties of exogenous targeted fluorescent molecular probes such as those used in optical MOLECULAR IMAGING, or nontargeted optical CONTRAST AGENTS.

Self-generated faint acoustic signals from the inner ear (COCHLEA) without external stimulation. These faint signals can be recorded in the EAR CANAL and are indications of active OUTER AUDITORY HAIR CELLS. Spontaneous otoacoustic emissions are found in all classes of land vertebrates.

Rapid methods of measuring the effects of an agent in a biological or chemical assay. The assay usually involves some form of automation or a way to conduct multiple assays at the same time using sample arrays.

Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.

Quick Search


DeepDyve research library

Relevant Topic

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...


Searches Linking to this Article