Combined SERS Emissions for High-throughput Optical Labels on Micron-scale Objects.

08:00 EDT 11th October 2019 | BioPortfolio

Summary of "Combined SERS Emissions for High-throughput Optical Labels on Micron-scale Objects."

High-throughput optical labeling technologies have become increasingly important with the growing demands for molecular detection, disease diagnosis, and drug discovery. In this thought, a series of CN-bridged coordination polymer encapsulated gold nanoparticles have been developed as a universal and interference-free optical label through a facile and auxiliary agent-free self-assembly route. Moreover, surface-enhanced Raman scattering (SERS) emissions of CN-bridge can be tuned flexibly by simple replacement of Fe2+/Fe3+ with other metal ions relying on synthesis of three Prussian blue analogues encapsulated gold nanoparticles (Au@PBA NPs). Thus, three distinct distinct Raman frequencies have been acquired, merely replaed the metal irons. Based on the potential super-multiplex optical label, space-confined surface-enhanced Raman scattering (SERS) emissions has been realized. Relying on 'Abbe theorem', the focused laser allows the pure and single triple bond-coded SERS emissions being combined into a unique and independent output, so called 'combined SERS emission' (c-SERS), if the Au@PBA NPs were confined into one micron-scale object. This study demonstrated c-SERS may simultaneously provide 2n-1 optical labels only using n single emissions in Raman-silent region for micron-size objects.


Journal Details

This article was published in the following journal.

Name: Analytical chemistry
ISSN: 1520-6882


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