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Lanthanide-doped nanocrystals (Ln3+-NCs) have shown great promise in the luminescence imaging of living cells and deep tissues. However, currently it remains challenging to readily engineer hydrophobic Ln3+-NCs with hydrophilicity and molecular recognition ability. Herein, we present an effective strategy to circumvent such a bottleneck by encapsulating Ln3+-NCs in graphene oxide (NCs@GO). Monodisperse NCs@GO was prepared via optimizing GO size and core-shell structure of NaYF4:Yb,Er@NaYF4, thus combining intense visible/near-infrared II (NIR-II) luminescence of NCs and the unique surface properties and biomedical functions of GO. Such binary nanostructure not only features broad solvent dispersibility, efficient cell uptake and excellent biocompatibility, but also enables further modifications with various agents, ranging from DNA, protein to nanoparticle without tedious conjugate procedures. Moreover, we demonstrate in proof-of-concept experiments that, NCs@GO is capable of realizing simultaneous intracellular tracking and microRNA-21 visualization, as well as highly sensitive in vivo tumor-targeted NIR-II imaging at 1525 nm. Such unique luminescent nanoprobes may stimulate the development of novel imaging paradigms for versatile applications.
This article was published in the following journal.
Name: Angewandte Chemie (International ed. in English)
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Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
Lanthanum. The prototypical element in the rare earth family of metals. It has the atomic symbol La, atomic number 57, and atomic weight 138.91. Lanthanide ion is used in experimental biology as a calcium antagonist; lanthanum oxide improves the optical properties of glass.
Food derived from genetically modified organisms (ORGANISMS, GENETICALLY MODIFIED).
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
A neuropathy due to VITAMIN B 12 DEFICIENCY or to excessive NITROUS OXIDE inhalation. It is associated with overproduction of the myelinolytic TUMOR NECROSIS FACTOR-ALPHA.
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...