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Graphene Oxide Modified Lanthanide Nanoprobes for Tumor-Targeted Visible/NIR-II Luminescence Imaging.

08:00 EDT 11th October 2019 | BioPortfolio

Summary of "Graphene Oxide Modified Lanthanide Nanoprobes for Tumor-Targeted Visible/NIR-II Luminescence Imaging."

Lanthanide-doped nanocrystals (Ln3+-NCs) have shown great promise in the luminescence imaging of living cells and deep tissues. However, currently it remains challenging to readily engineer hydrophobic Ln3+-NCs with hydrophilicity and molecular recognition ability. Herein, we present an effective strategy to circumvent such a bottleneck by encapsulating Ln3+-NCs in graphene oxide (NCs@GO). Monodisperse NCs@GO was prepared via optimizing GO size and core-shell structure of NaYF4:Yb,Er@NaYF4, thus combining intense visible/near-infrared II (NIR-II) luminescence of NCs and the unique surface properties and biomedical functions of GO. Such binary nanostructure not only features broad solvent dispersibility, efficient cell uptake and excellent biocompatibility, but also enables further modifications with various agents, ranging from DNA, protein to nanoparticle without tedious conjugate procedures. Moreover, we demonstrate in proof-of-concept experiments that, NCs@GO is capable of realizing simultaneous intracellular tracking and microRNA-21 visualization, as well as highly sensitive in vivo tumor-targeted NIR-II imaging at 1525 nm. Such unique luminescent nanoprobes may stimulate the development of novel imaging paradigms for versatile applications.

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This article was published in the following journal.

Name: Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
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