Ghrelin abates bacterial translocation following burn injury by improving gastric emptying.

08:00 EDT 11th October 2019 | BioPortfolio

Summary of "Ghrelin abates bacterial translocation following burn injury by improving gastric emptying."

In severe burns, increased intestinal permeability facilitates bacterial translocation, resulting in systemic endotoxemia and multi organ failure. We investigated the role of burn-induced gastrointestinal dysmotility (BIGD) in promoting bacterial translocation following burn injury, and the protective effect of ghrelin in this process.


Journal Details

This article was published in the following journal.

Name: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
ISSN: 1365-2982
Pages: e13742


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Medical and Biotech [MESH] Definitions

A 28-amino acid, acylated, orexigenic peptide that is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin.

The passage of viable bacteria from the gastrointestinal tract to extra-intestinal sites, such as the mesenteric lymph node complex, liver, spleen, kidney, and blood. Factors that promote bacterial translocation include overgrowth with gram-negative enteric bacilli, impaired host immune defenses, and injury to the intestinal mucosa resulting in increased intestinal permeability. These mechanisms can act in concert to promote synergistically the systemic spread of indigenous translocating bacteria to cause lethal sepsis.

Transmembrane proteins that recognize and bind GHRELIN, a potent stimulator of GROWTH HORMONE secretion and food intake in mammals. Ghrelin receptors are found in the pituitary and HYPOTHALAMUS. They belong to the family of G-PROTEIN-COUPLED RECEPTORS.

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