Functional Implications of Ca 2.3 R-Type Voltage-Gated Calcium Channels in the Murine Auditory System - Novel Vistas from Brainstem-Evoked Response Audiometry.

08:00 EDT 11th October 2019 | BioPortfolio

Summary of "Functional Implications of Ca 2.3 R-Type Voltage-Gated Calcium Channels in the Murine Auditory System - Novel Vistas from Brainstem-Evoked Response Audiometry."

Voltage-gated Ca channels (VGCCs) are considered to play a key role in auditory perception and information processing within the murine inner ear and brainstem. In the past, Ca 1.3 L-type VGCCs gathered most attention as their ablation causes congenital deafness. However, isolated patch-clamp investigation and localisation studies repetitively suggested that Ca 2.3 R-type VGCCs are also expressed in the cochlea and further components of the ascending auditory tract, pointing to a potential functional role of Ca 2.3 in hearing physiology. Thus, we performed auditory profiling of Ca 2.3 controls, heterozygous Ca 2.3 mice and Ca 2.3 null mutants (Ca 2.3 ) using brainstem evoked response audiometry. Interestingly, click evoked auditory brainstem responses (ABRs) revealed increased hearing thresholds in Ca 2.3 mice from both genders, whereas no alterations were observed in Ca 2.3 mice. Similar observations were made for tone-burst related ABRs in both genders. However, Ca 2.3 ablation seemed to prevent mutant mice from total hearing loss particularly in the higher frequency range (36 - 42 kHz). Amplitude growth function analysis revealed i.a., significant reduction in ABR wave W and W amplitude in mutant animals. In addition, alterations in W -W inter-wave interval were observed in female Ca 2.3 mice whereas absolute latencies remained unchanged. In summary, our results demonstrate that Ca 2.3 VGCCs are mandatory for physiological auditory information processing in the ascending auditory tract.


Journal Details

This article was published in the following journal.

Name: The European journal of neuroscience
ISSN: 1460-9568


DeepDyve research library

PubMed Articles [20537 Associated PubMed Articles listed on BioPortfolio]

Regulation of voltage-gated calcium channels by the ER calcium sensor STIM1.

The endoplasmic reticulum (ER) Ca sensor STIM1, best-known for its essential role in triggering influx of extracellular Ca via Ca-release-activated channels when ER stores become depleted, unexpectedl...

Dynamic compartmentalization of calcium channel signalling in neurons.

Calcium fluxes through the neuronal membrane are strictly limited in time due to biophysical properties of voltage-gated and ligand-activated ion channels and receptors. Being embedded into the crowde...

Disruption of the Key Ca Binding Site in the Selectivity Filter of Neuronal Voltage-Gated Calcium Channels Inhibits Channel Trafficking.

Voltage-gated calcium channels are exquisitely Ca selective, conferred primarily by four conserved pore-loop glutamate residues contributing to the selectivity filter. There has been little previous w...

Diffuse microdamage in bone activates anabolic response by osteoblasts via involvement of voltage-gated calcium channels.

Matrix damage sustained by bone tissue is repaired by the concerted action of bone cells. Previous studies have reported extracellular calcium ([Ca]) efflux to originate from regions of bone undergoin...

Reversal of peripheral neuropathic pain by the small-molecule natural product physalin F via block of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.

No universally efficacious therapy exists for chronic pain, a disease affecting one-fifth of the global population. An overreliance in the prescription of opioids for chronic pain despite their poor a...

Clinical Trials [9931 Associated Clinical Trials listed on BioPortfolio]

Detection of Cav1 Calcium Channels in Inflammatory Cells of Asthmatic Children

Asthma affects about 10% of children and 6% of adults in industrialized countries. Lymphocytes (L) Th2, a T cell population (LT) producing interleukin (IL) -4, 5 and 13 are broadly involve...

Targeting Potassium Channels to Reprogram Glioblastoma Microenvironment: in Vitro and in Vivo Studies

The investigators want to verify the hypothesis that targeting the calcium-activated (KCa3.1) and the voltage-dependent K channel (Kv1.3) could be a valuable therapeutic strategy to reprog...

Cognitive Effects of Nimodipine in Patients With Schizophrenia

This study aims to evaluate the acute effects of nimodipine on cognitive performance in patients with schizophrenia using a battery of cognitive assessments.The subjects will also complete...

Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging

The purpose of this study is to learn what changes in blood vessel contraction may occur as a result of a disease of the vessel that requires surgery. The study will examine the calcium ch...

Opioid Induced Loss of Local Anesthetic Potency in Patients Undergoing Total Knee Arthroplasty

Peripheral nerve blocks with local anesthetics (LAs) have become an integral part of postoperative pain management particularly for patients undergoing major limb procedures such as such a...

Medical and Biotech [MESH] Definitions

Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.

CALCIUM CHANNELS that are concentrated in neural tissue. Omega toxins inhibit the actions of these channels by altering their voltage dependence.

A heterogenous group of transient or low voltage activated type CALCIUM CHANNELS. They are found in cardiac myocyte membranes, the sinoatrial node, Purkinje cells of the heart and the central nervous system.

A neuropeptide toxin from the venom of the funnel web spider, Agelenopsis aperta. It inhibits CALCIUM CHANNELS, P-TYPE by altering the voltage-dependent gating so that very large depolarizations are needed for channel opening. It also inhibits CALCIUM CHANNELS, Q-TYPE.

Compounds that either stimulate the opening or prevent closure of VOLTAGE-GATED SODIUM CHANNELS.

Quick Search

DeepDyve research library

Relevant Topics

Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Hearing, auditory perception, or audition is the ability to perceive sound by detecting vibrations, changes in the pressure of the surrounding medium through time, through an organ such as the ear. Sound may be heard through solid, liquid, or gaseous mat...

Searches Linking to this Article