Haemodynamic evaluation of the new pulsatile-flow generation method in vitro.

08:00 EDT 11th October 2019 | BioPortfolio

Summary of "Haemodynamic evaluation of the new pulsatile-flow generation method in vitro."

Continuous-flow ventricular-assist devices are widely used to support patients with advanced heart failure, because continuous-flow ventricular-assist devices are more durable, have smaller sizes and have better survival rates for patients compared to the pulsatile-flow ventricular-assist devices. Nevertheless, continuous-flow ventricular-assist devices often cause complications such as gastrointestinal bleeding, haemorrhagic stroke, and aortic insufficiency and have a negative impact on the microcirculation for both long-time implantable and short-time extracorporeal systems. The aim of this study is the evaluation of the pulsatile-flow generation method in continuous-flow ventricular-assist device without pump speed changes. The method may be used for short-time extracorporeal continuous-flow mechanical circulatory support and long-time implantable mechanical circulatory support. A shunt with a controlled adjustable valve, that clamps periodically, is connected in parallel to the continuous-flow ventricular-assist device. We compared the continuous-flow ventricular-assist device operating with and without the shunt on the mock circulation loop. The continuous-flow ventricular-assist device-shunt system was connected according to the left ventricle-aorta circuit and worked in phase with the ventricle. Heart failure was simulated on the mock circulation circuit. Rotaflow (Maquet Inc.) was used as the continuous-flow pump. Haemolysis studies of the system for generating a pulse flow were carried out at a flow rate of 5 L/min and a pressure drop of 100 mm Hg. To compare the haemodynamic efficiency, we used the aortic pulsation index , the equivalent energy pressure and the surplus haemodynamic energy. These indexes were higher in the pulsatile mode ( - 4 times, equivalent energy pressure by 7.36% and surplus haemodynamic energy - 10 times), while haemolysis was the same. The normalised index of haemolysis was 0.0015 ± 0.001. The results demonstrate the efficiency of the pulsatile-flow generation method for continuous-flow ventricular-assist devices without impeller rotation rate changes.


Journal Details

This article was published in the following journal.

Name: The International journal of artificial organs
ISSN: 1724-6040
Pages: 391398819879939


DeepDyve research library

PubMed Articles [24367 Associated PubMed Articles listed on BioPortfolio]

Optical Flow Sensor for Continuous Invasive Measurement of Blood Flow Velocity.

Continuous monitoring of intrapulse measurement of blood flow in humans is currently not achievable with clinically available instruments. In this paper, we demonstrate a method of measuring the insta...

Shape-appearance constrained segmentation and separation of vein and artery in pulsatile tinnitus patients based on MR angiography and flow MRI.

This study reports on the development and evaluation of a novel segmentation method for extracting the internal jugular vein and the adjacent carotid artery from magnetic resonance (MR) images of pati...

A 4D Flow MRI Evaluation of the Impact of Shear-Dependent Fluid Viscosity on in vitro Fontan Circulation Flow.

The Fontan procedure for univentricular heart defects creates a non-physiologic circulation where systemic venous blood drains directly into the pulmonary arteries, leading to multiorgan dysfunction s...

Comparison of heart transplant outcomes between recipients with pulsatile- vs continuous-flow LVAD.

Continuous-flow (CF) left ventricular assist devices (LVADs) have replaced pulsatile flow (PF) LVADs irrespective of concerns from the physiologic changes/morbidity secondary to lack of pulsatility. D...

In-Vitro evaluation of an adaptive Starling-like controller for dual Rotary ventricular assist devices.

Rotary ventricular assist devices (VADs) operated clinically under constant speed control (CSC) cannot respond adequately to changes in patient cardiac demand, resulting in sub-optimal VAD flow regula...

Clinical Trials [8606 Associated Clinical Trials listed on BioPortfolio]

The Impact of Non-pulsatile Blood Flow on CO2-Reactivity

The investigators hypothezised that CO2-reactivity of cerebral vessels is affected by systemic non-pulsatile blood flow. Patients undergoing elective cardiac surgery with CPB were enrolled...

Impact of Pulsatile Cardio-Pulmonary Bypass (CPB) on Vital Organ Recovery

This research study is about the effect heart-lung bypass procedures have on the vital organs (brain, heart, lungs, and kidneys) during open-heart surgery in pediatric patients. There are ...

Pulsatile Perfusion Preservation in Kidney Transplantation From Expanded Criteria Donors

Our hypothesis is that the Waters Medical® pulsatile perfusion machine (RM 3) is a way to improve delayed graft function (DGF) in marginal grafts, and some perfusion profiles (flow, press...

Non-invasive Haemodynamic Monitoring in Pregnancy

This prospective and observational trial over 55 pregnant women (third trimester) compares non invasive haemodynamic monitoring using Nexfin technology and ultrasonography technic

Peripheral and Mesenteric Perfusion in Elective Surgical Patients

An important goal of haemodynamic monitoring and resuscitation is early detection of insufficient tissue perfusion and oxygenation. The mesenteric haemodynamic response to circulatory shoc...

Medical and Biotech [MESH] Definitions

Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.

Measurement of light given off by fluorescein in order to assess the integrity of various ocular barriers. The method is used to investigate the blood-aqueous barrier, blood-retinal barrier, aqueous flow measurements, corneal endothelial permeability, and tear flow dynamics.

Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.

The technique of maintaining or growing mammalian EMBRYOS in vitro. This method offers an opportunity to observe EMBRYONIC DEVELOPMENT; METABOLISM; and susceptibility to TERATOGENS

Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.

Quick Search

DeepDyve research library

Relevant Topic

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...

Searches Linking to this Article