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Association of GCK gene DNA methylation with the risk of clopidogrel resistance in acute coronary syndrome patients.

08:00 EDT 11th October 2019 | BioPortfolio

Summary of "Association of GCK gene DNA methylation with the risk of clopidogrel resistance in acute coronary syndrome patients."

Clopidogrel resistance (CR), which was manifested as the failure of platelet inhibition in clopidogrel treatment, was likely to lead to cardiovascular events. Our study was aimed to explore the contribution of DNA methylation in glucokinase (GCK) to the CR risk.

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Journal Details

This article was published in the following journal.

Name: Journal of clinical laboratory analysis
ISSN: 1098-2825
Pages: e23040

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Medical and Biotech [MESH] Definitions

The ability of viruses to resist or to become tolerant to chemotherapeutic agents or antiviral agents. This resistance is acquired through gene mutation.

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A DNA (cytosine-5-)-methyltransferase that contains a central CxxC type zinc finger motif. It binds poly(ADP)-ribose and its expression is regulated by POLY (ADP-RIBOSE) POLYMERASE-1. DNMT1 methylates CpG residues, with a preference for hemimethylated DNA, and associates with DNA replication sites in S PHASE to maintain the methylation pattern in the newly synthesized strand, which is essential for EPIGENETIC PROCESSES. It also associates with CHROMATIN during G2 PHASE and MITOSIS to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development; mutations in the DNMT1 gene are associated with HEREDITARY SENSORY NEUROPATHY TYPE 1 class E.

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