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Modeling Drug Exposure in Rodents using e-Cigarettes and other Electronic Nicotine Delivery Systems.

08:00 EDT 12th October 2019 | BioPortfolio

Summary of "Modeling Drug Exposure in Rodents using e-Cigarettes and other Electronic Nicotine Delivery Systems."

Smoking tobacco products is the leading cause of preventable death worldwide. Coordinated efforts have successfully reduced tobacco cigarette smoking in the United States; however, electronic cigarettes (e-cigarette) and other electronic nicotine delivery systems (ENDS) recently have replaced traditional cigarettes for many users. While the clinical risks associated with long-term ENDS use remain unclear, advancements in preclinical rodent models will enhance our understanding of their overall health effects. This review examines the peripheral and central effects of ENDS-mediated exposure to nicotine and other drugs of abuse in rodents and evaluates current techniques for implementing ENDS in preclinical research.

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This article was published in the following journal.

Name: Journal of neuroscience methods
ISSN: 1872-678X
Pages: 108458

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Medical and Biotech [MESH] Definitions

Electronic devices that are designed to provide NICOTINE in the form of an inhaled aerosol. They typically are made in the shape of CIGARETTES in order to simulate the experience of CIGARETTE SMOKING.

The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.

The act of inhaling and exhaling vapors produced from ELECTRONIC CIGARETTES.

Electronic implements worn on the body as an implant or as an accessory. Examples include wearable diagnostic devices, wearable ACTIVITY TRACKERS, wearable INFUSION PUMPS, wearable computing devices, SENSORY AIDS, and electronic pest repellents.

Electronic devices that increase the magnitude of a signal's power level or current.

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