Prolyl Hydroxylase Inhibition Mitigates Pouchitis.

08:00 EDT 16th October 2019 | BioPortfolio

Summary of "Prolyl Hydroxylase Inhibition Mitigates Pouchitis."

Pouchitis is the most common long-term complication after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) or familial adenomatous polyposis (FAP), which can eventually progress to pouch failure, necessitating permanent stoma construction. Hypoxia-inducible transcription factor prolyl hydroxylase-containing enzymes (PHD1, PHD2, and PHD3) are molecular oxygen sensors that control adaptive gene expression through hypoxia-inducible factor (HIF). Emerging evidence supports PHDs as being therapeutic targets in intestinal inflammation. However, pharmacological inhibition of PHDs has not been validated as a treatment strategy in pouchitis.


Journal Details

This article was published in the following journal.

Name: Inflammatory bowel diseases
ISSN: 1536-4844


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