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A Pd-catalyzed asymmetric allylic substitution cascade of allylic meso-dicarbonates with 3-oxo-nitriles has been developed for the synthesis of chiral bicyclic dihydrofurans bearing two vicinal carbon stereocenters. The reaction proceeds via an asymmetric desymmetrization process with the desired products being obtained in high yields and with up to 97% ee. The reaction was performed on a gram-scale and the corresponding bicyclic dihydrofurans could undergo several transformations. The methodology provides an efficient synthetic route to biologically active chiral bicyclic dihydrofurans derivatives.
This article was published in the following journal.
Name: Chemical communications (Cambridge, England)
The synthesis of P-chiral compounds is a challenging task, especially since useful catalytic methods for preparing such molecules are scarce. Herein we disclose a desymmetrization that employs phosphi...
An efficient method for the enantioselective synthesis of cyclic ureas has been developed through Pd-catalyzed asymmetric allylic cycloaddition of readily accessible nitrogen-containing allylic carbon...
A chiral N-heterocyclic-carbene-catalyzed cascade asymmetric desymmetrization reaction of cyclopentenediones with enals has been successfully initiated, followed with tandem aldol annulation, aromatiz...
A palladium-catalyzed C‒H functionalization/intramolecular asymmetric allylation cascade of N-sulfonyl benzamides with 1,3-dienes has been developed. In the presence of a chiral pyridine-oxazoline l...
A highly enantioselective rhodium-catalyzed allylic dearomatization of β-naphthols with racemic aryl vinyl carbinol is described. In the presence of a Rh-catalyst derived from [Rh(CH)Cl] and chiral (...
Asthma, a disease characterized by chronic airway inflammation and hyper -responsiveness, is a common disease that affects all age groups. Asthma may be manifested as irreversible airflow ...
The purpose of this study is to evaluate safety and efficacy of corneal cross-linking and photorefractive keratectomy for refractive correction in patients with bilateral asymmetric topogr...
The purpose of this study is to evaluate the effect of asymmetric spinal stabilization exercise on scoliosis
This study will assess changes in visual acuity and corneal symmetry after corneal collagen cross-linking (CXL) of asymmetric corneas.
The aim of the study is to identify the role of diffusion weighted MRI in the assessment of the clinical significance and outcomes of asymmetric breast densities identified on mammograms, ...
Enzymes that catalyze inversion of the configuration around an asymmetric carbon in a substrate having one (racemase) or more (epimerase) center(s) of asymmetry. (Dorland, 28th ed) EC 5.1.
A uroplakin subtype that heterodimerizes with UROPLAKIN IB to form a component of the asymmetric unit membrane found in urothelial cells.
A uroplakin subtype that heterodimerizes with UROPLAKIN IA to form a component of the asymmetric unit membrane found in urothelial cells.
A tetraspanin domain-containing uroplakin subtype. It heterodimerizes with UROPLAKIN II to form a component of the asymmetric unit membrane found in urothelial cells.
A tetraspanin domain-containing uroplakin subtype. It heterodimerizes with UROPLAKIN III to form a component of the asymmetric unit membrane found in urothelial cells.