New Lignans from roots of Kadsura coccinea.

08:00 EDT 16th October 2019 | BioPortfolio

Summary of "New Lignans from roots of Kadsura coccinea."

Four new dibenzocyclooctadiene lignans, named heilaohusus A-D (1-4), one new arylnaphthalene lignan named heilaohusu E (5), and seven known analogues (6-12) were isolated from the roots of Kadsura coccinea. Their structures and configurations were elucidated by a combination of HR-ESI-MS, H NMR, C NMR, HSQC, HMBC, NOESY and CD spectra. Among the known compounds, compounds 6 and 8-12 were isolated from this plant for the first time. All of compounds were evaluated for their cytotoxicity activities, compounds 3, 6 and 7 showed weak cytotoxicity against four human cancer cell lines (HepG-2, HCT-116, BGC-823 and Hela) with IC values range from 13.04 to 21.93 μM. Compounds 1 and 7 demonstrated potential anti-RA (rheumatoid arthritis) activity against RA-FLS cell line with IC values of 14.57 and 11.70 μM, respectively.


Journal Details

This article was published in the following journal.

Name: Fitoterapia
ISSN: 1873-6971
Pages: 104368


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Medical and Biotech [MESH] Definitions

A plant genus of the family SCHISANDRACEAE. Members contain schisandrins (Russian) which are also called gomisins (Japanese) or wuweizins (Chinese). The compounds in this genus are very similar to those in the related KADSURA and medicinal usage is very similar. It is sometimes adulterated with KADSURA.

A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.

Root-like underground horizontal stem of plants that produces shoots above and roots below. Distinguished from true roots which don't have buds and nodes. Similar to true roots in being underground and thickened by storage deposits.

A plant genus of the family SCHISANDRACEAE that is used in folk medicine much like SCHISANDRA. Members contain kadsurenone and kadsurin.

The paired bundles of nerve fibers entering and leaving the spinal cord at each segment. The dorsal and ventral nerve roots join to form the mixed segmental spinal nerves. The dorsal roots are generally afferent, formed by the central projections of the spinal (dorsal root) ganglia sensory cells, and the ventral roots efferent, comprising the axons of spinal motor and autonomic preganglionic neurons. There are, however, some exceptions to this afferent/efferent rule.

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