Mechanical properties of highly porous PEEK bionanocomposites incorporated with carbon and hydroxyapatite nanoparticles for scaffold applications.

08:00 EDT 19th October 2019 | BioPortfolio

Summary of "Mechanical properties of highly porous PEEK bionanocomposites incorporated with carbon and hydroxyapatite nanoparticles for scaffold applications."

Bone regeneration is of great importance worldwide, because of various bone diseases, such as infections, tumors, and resultant fracture, birth defects, and bone loss due to trauma, explosion, or accident. Bone regeneration can be achieved by several materials and templates manufactured through various fabrication techniques. Uses of different materials and scaffold fabrication techniques have been explored over the past 20 years. In this research, polyetheretherketone (PEEK) was used to fabricate highly porous bionanocomposite foams for bone scaffolding. Melt casting and salt porogen (200-500 µm size) leaching methods were adapted to create an adequate pore size and the necessary percent of porosity, because pore size plays a vital role in cell implantation and growth. Porosity (75% and 85%) of the prepared scaffolds was adjusted by changing salt concentrations in the PEEK powder. Hydroxyapatite (HA) and carbon particles were used to improve cell attachments and interactions with the porous PEEK and to increase the mechanical properties of the scaffold materials. Carbon fiber (CF) and carbon nanotubes (CNTs) were uniformly dispersed into the PEEK powder before melt casting to enhance the mechanical properties and to observe the influence of the carbon particles on the properties of PEEK bionanocomposite foam. Compression test results of the fabricated bionanocomposites showed that HA and carbon particles are the potential filler materials for the enhancement of bionanocomposite mechanical properties. About 186% enhancement of compression modulus and 43% enhancement of yield strength were observed while incorporating only 0.5 wt% of CNTs into PEEK/HA bionanocomposites having 75% porosity, compared to PEEK/HA 20 wt% bionanocomposites. Micro-computed tomography (micro-CT) test results reveal that pore size and interconnectivity of the nanocomposite foams are in order and within the designed sizes. Mechanical tests proved that PEEK bionanocomposite foam has the potential for use in bone scaffolding and other biomedical applications.


Journal Details

This article was published in the following journal.

Name: Progress in biomaterials
ISSN: 2194-0509


DeepDyve research library

PubMed Articles [14008 Associated PubMed Articles listed on BioPortfolio]

Does annealing improve the interlayer adhesion and structural integrity of FFF 3D printed PEEK lumbar spinal cages?

Polyaryletheretherketone (PEEK) has been commonly used for interbody fusion devices because of its biocompatibility, radiolucency, durability, and strength. Although the technology of PEEK Additive Ma...

Application of polyetheretherketone and its composite as frameworks in fixed dental prostheses.

Characterized by eminent mechanical properties, chemical stability and biosafety, polyetheretherketone (PEEK), as a brand-new type of biomedical material, has been applied in the field of stomatology....

Surface sulfonation and nitrification enhance the biological activity and osteogenesis of polyetheretherketone by forming an irregular nano-porous monolayer.

Polyether-ether-ketone (PEEK) is becoming a popular component of clinical spinal and orthopedic applications, but its practical use suffers from several limitations. In this study, irregular nano-poro...

The influence of polycaporolacton fumarate coating on mechanical properties and in vitro behavior of porous diopside-hardystonite nano-composite scaffold.

One of the significant challenges in bone tissue engineering is the fabrication of highly porous scaffolds with interconnected pores and appropriate mechanical properties. Artificial scaffolds which u...

Structural stability of a polyetheretherketone femoral component-A 3D finite element simulation.

Because its mechanical properties are similar to cortical bones of the knee, polyetheretherketone (PEEK) material has been used to make total knee arthroplasty (TKA) components. This study investigate...

Clinical Trials [4211 Associated Clinical Trials listed on BioPortfolio]

3D-printed Porous Titanium Alloy Cages Versus PEEK Cages in Patients With Osteoporosis

This is a prospective,observational single-center study. The osteoporotic patients requiring posterior lumbar interbody fusion(PLIF) with cages at the lowest fusion segment are prospective...

Evaluation of Soft Tissue Profile Changes Following Autogenous Fat or Onlay Polyetheretherketone (PEEK) Augmentation Versus Sliding Genioplasty for Correction of Deficient Chin

Fat is a filler with ideal properties as it naturally integrates into tissues with 100 % biocompatibility. Moreover, fat contains different cell types, including adipocytes, fibroblasts, s...

Polyetheretherketone vs Cobalt-chromium Telescopic Removable Partial Denture in Kennedy Class I Patients Regarding Oral Health Related Quality of Life

Dentistry is a rapidly progressing field with innumerable advances taking place on a day to day basis. The application of newer technologies and materials has advanced the specialty of pro...

One Year Clinical Evaluation of Milled BioHPP (PEEK) Versus Zirconia Veneered Single Crowns (RCT-one-year Evaluation).

All ceramic crowns are indicated in case of mild to moderate discoloration, restoration of traumatized or fractured teeth and abnormal tooth anatomy. Long term success of all ceramic crown...

Porous Metronidazole Loaded Matrix for Local Treatment of Periodontitis.

Aim of the study is the efficiency assessment of porous Metronidazole loaded matrix based on gelatin/hydroxyethylcellulose blend in treatment of deep periodontal pockets resulting from sev...

Medical and Biotech [MESH] Definitions

The properties and processes of materials that affect their behavior under force.

The properties, processes, and behavior of biological systems under the action of mechanical forces.

A group of homologous proteins which form the intermembrane channels of GAP JUNCTIONS. The connexins are the products of an identified gene family which has both highly conserved and highly divergent regions. The variety contributes to the wide range of functional properties of gap junctions.

Mechanical devices used to produce or assist pulmonary ventilation.

Diamond nanoparticles that exhibit unique biological, thermal, mechanical, and optoelectronic properties. They have important NANOMEDICINE applications including DRUG DELIVERY SYSTEMS; DIAGNOSTIC IMAGING; protein separation; and BIOSENSING TECHNIQUES.

Quick Search

DeepDyve research library

Relevant Topic

Osteoporosis is a disease in which the bones become extremely porous, are subject to fracture, and heal slowly, occurring especially in women following menopause and often leading to curvature of the spine from vertebral collapse. Follow and track&n...

Searches Linking to this Article