RAPID COMMUNICATION: Dietary tributyrin supplementation and submaximal exercise promote activation of equine satellite cells.

08:00 EDT 20th October 2019 | BioPortfolio

Summary of "RAPID COMMUNICATION: Dietary tributyrin supplementation and submaximal exercise promote activation of equine satellite cells."

Post-exercise skeletal muscle repair is dependent upon the actions of satellite cells (SCs). The signal(s) responsible for activation of these normally quiescent cells in the horse remain unknown. The objective of the experiment was to determine if submaximal exercise or tributyrin (TB) supplementation are sufficient to stimulate SC activation. Adult geldings were fed a control diet (n=6) or a diet containing 0.45% TB (n=6). After 30 d, the geldings performed a single bout of submaximal exercise. Middle gluteal muscle biopsies and blood were collected on d -1, 1 , 3 and 5 relative to exercise. Diet had no effect on any parameter of physical performance. Total RNA isolated from the gluteal muscle of TB fed geldings contained greater (P < 0.05) amounts of myogenin mRNA than controls. Satellite cell isolates from TB supplemented horses had a greater (P = 0.02) percentage of proliferating cell nuclear antigen immunopositive (PCNA+) SC than controls after 48 h in culture. Submaximal exercise was sufficient to increase (P < 0.05) the percentage of PCNA(+) cells in all isolates obtained during recovery period. No change in the amount of gluteal muscle Pax7 mRNA, a lineage marker of satellite cells, occurred in response to either diet or exercise. Our results indicate that both submaximal exercise and TB prime SCs for activation and cell cycle reentry but are insufficient to cause an increase in Pax7 expression during the recovery period.


Journal Details

This article was published in the following journal.

Name: Journal of animal science
ISSN: 1525-3163


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