Drug delivery and targeting to the brain through nasal route: Mechanisms, Applications and Challenges.

08:00 EDT 29th October 2019 | BioPortfolio

Summary of "Drug delivery and targeting to the brain through nasal route: Mechanisms, Applications and Challenges."

Blood brain barrier (BBB) provide restrictions for the transportation of various therapeutic agents to the brain. Efforts to directly target the brain by olfactory as well as trigeminal nerve pathway, bypassing BBB have grown significantly in recent times. Intranasal route of transportation of the drug encompasses ability for the delivery of drug directly to brain, improve site specificity in the brain and avoiding systemic side effects. In current era, novel drug delivery systems are useful tools for targeting brain without providing any harmful effects in nasal mucosa as well as central nervous system. Complex structure of nasal cavity, mucociliary clearance, degradation by the enzymes present in nasal cavity and pathological conditions like rhinitis, common cold, etc. are the major disputes for nasal drug delivery. But the use of nanotechnological approaches like solid lipid nanoparticles, polymeric nanoparticles, nanoemulsions, liposomes, polymeric micelles provides the ability to overcome these barriers. There are several emerging nasal drug delivery technologies produced by various pharmaceutical companies to conquer these hurdles. This review tries to address the recent developments in the area of direct drug delivery to the brain through nasal route.


Journal Details

This article was published in the following journal.

Name: Current drug delivery
ISSN: 1875-5704


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Medical and Biotech [MESH] Definitions

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A specific category of drugs that prevent sleepiness by specifically targeting sleep-mechanisms in the brain. They are used to treat DISORDERS OF EXCESSIVE SOMNOLENCE such as NARCOLEPSY. Note that this drug category does not include broadly-acting central nervous system stimulants such as AMPHETAMINES.

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