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Role of aspirin-triggered lipoxin A4, aspirin and salicylic acid in the modulation of the oxidative and inflammatory responses induced by plasma from women with preeclampsia.

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Summary of "Role of aspirin-triggered lipoxin A4, aspirin and salicylic acid in the modulation of the oxidative and inflammatory responses induced by plasma from women with preeclampsia."

Oxidative stress and inflammation are key events leading to preeclampsia, involved in several maternal deaths. Low doses of Acetylsalicylic acid (ASA) are used in prevention and treatment of preeclampsia. The synthesis of aspirin-triggered lipoxin (ATL) by cyclooxygenase-2 acetylation is an alternative mechanism of ASA, which could explain the effectiveness of ASA treatments. The aim of this study was to evaluate the role of ASA, salicylates and ATL in the modulation of the oxidative and inflammatory responses induced by plasma from women with preeclampsia.

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This article was published in the following journal.

Name: American journal of reproductive immunology (New York, N.Y. : 1989)
ISSN: 1600-0897
Pages: e13207

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