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Methanol is a very promising feedstock alternative to sugar-based raw materials for biomanufacturing because it does not compete with food production, is abundant and potentially sustainable in the future. Although methylotrophic fermentations have been practiced for decades, their applications are limited by technical drawbacks and insufficient knowledge of the physiology and metabolic regulation of native methylotrophs. Synthetic biology offers great opportunities for engineering efficient methylotrophic microbial cell factories by enabling non-methylotrophic model organisms to utilize methanol via the introduction of C1 utilization pathways. This review critically comments C1 metabolism with a focus on comparing different methanol-utilization pathways in light of biomanufacturing, and highlights recent advances in the engineering of synthetic methylotrophs. Most importantly, the unique challenges in the engineering process and possible solutions are also discussed in detail.
This article was published in the following journal.
Name: Biotechnology advances
Engineering microbial cell factories is a potential approach of sustainable production of chemicals, fuels and pharmaceuticals. However, testing the production of molecules in high throughput is still...
Methylotuvimicrobium alcaliphilum 20Z is a promising platform strain for bioconversion of one-carbon (C1) substrates into value-added products. To carry out robust metabolic engineering with methylotr...
Cyanobacteria photosynthetic biomanufacturing provides a promising technology route for green development, but an efficient photosynthesis system is required for economical competitive performance. Sy...
Lactobacillus reuteri is a heterofermentative Lactic Acid Bacterium (LAB) that is commonly used for food fermentations and probiotic purposes. Due to its robust properties, it is also increasingly con...
Methanol is an attractive and broadly available substrate for large-scale bioproduction of fuels and chemicals. It contains more energy and electrons per carbon than carbohydrates and can be cheaply p...
aim to investigate the relationship between the RDW and 7-day mortality during acute methanol poisoning.
In this randomized controlled trial; differences in overall stress, burnout and wellbeing will be assessed for employees of a company participating in Inner Engineering Online, an online m...
This study intends to include any participant who has registered and plans to attend the Inner Engineering In-Person Completion Course. This course was offered at two time periods (March a...
The aim of this study is to perform the bone tissue engineering to reconstruct the alveolar bone defect in cleft lip and palate patients using mesenchymal stem cells from deciduous dental ...
This study is to try to maintain cultured dermal papilla cells in spherical structure in vitro before transplanting into dermis in vivo. Also, this study is aimed in clarifying actual mech...
Methods and techniques used to modify or select cells and develop conditions for growing cells for biosynthetic production of molecules (METABOLIC ENGINEERING), for generation of tissue structures and organs in vitro (TISSUE ENGINEERING), or for other BIOENGINEERING research objectives.
A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.
Application of principles and practices of engineering science to the transformation, design, and manufacture of substances on an industrial scale.
A branch of engineering concerned with the design, construction, and maintenance of environmental facilities conducive to public health, such as water supply and waste disposal.
Application of principles and practices of engineering science to biomedical research and health care.
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...
Food is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism ...