Track topics on Twitter Track topics that are important to you
For the early diagnosis of gastric cancer, microRNA-148a as a promising biomarker is measured by a simple colorimetric biosensor due to the unique surface plasmon resonance (SPR) absorption of gold nanoparticles (AuNPs). In the assay system, the sensing probes are facilitated by the conjugation of AuNPs with RNA probes (RNAP) vis Au-S bond, which align in a tail-to-tail fashion onto the target RNA. When miRNA-148a is introduced, the sandwich hybridization reaction is triggered between the AuNPs-RNAP conjugates and targets, resulting in changes in SPR absorption band, microscopic distribution and macroscopic color of the AuNPs solution. Following the principle, this colorimetric method is able to quantitatively detect miRNA-148a at nanomolar level with a limit of ~1.9 nM and exhibits high sensitivity and selectivity by a low-cost UV-Vis spectrometer or even naked eye. Moreover, the AuNPs network materials with a characteristic sharp "melting transition" provide significant guidance for the reusability of DNA or RNA biosensor.
This article was published in the following journal.
An aptamer-based colorimetric lateral flow assay was developed for the detection of human epidermal growth factor receptor 2 (HER2). In this study, two approaches were examined using HER2 binding apta...
An optical nanoprobe consisting of gold nanoclusters (AuNCs) and gold nanoparticles (AuNPs) is described for ultrasensitive detection of heparin (Hep). Polyethyleneimine (PEI) induces the aggregation ...
A fluorometric and colorimetric dual mode sensing platform based on hybridized carbon dots (Cdots) and gold-silver core-shell nanoparticles (Au@Ag NPs) has been established for the sensitive detection...
In this work, we demonstrated the development of a colorimetric immunosensor using surface plasmon resonance band of gold nanoparticles for the detection of prostate specific antigen (PSA). To develop...
G-quadruplexes formed by 3'-overhang of guanine-rich human telomeric DNA at the end of chromosome have important implication in inhibiting the telomerase activity. Telomerase catalyzes the elongation ...
Pancreatic cancer represents the most lethal of the common malignancies, with a 5-year survival rate of less than 5%. For patients who, when are diagnosed of pancreatic cancer, are eligibl...
Papillary thyroid cancer (PTC) is the most common subtype of thyroid cancer. The most common site of PTC nodal metastases is the central neck, which has a reported rate of lymph node meta...
Silver nanoparticles are one of most nanoparticles use nowadays in the research area because it has specific physical and chemical properties, in medical fields silver nanoparticles can in...
This study is a multi-center, prospective cohort study which are planned to enroll the 6000 patients who diagnosed the primary gastric cancer and 12,000 healthy normal cohort participants ...
This projective observational study is planned to enroll more than 300 advanced breast cancer patients, who were proved as Her-2 positive using fluorescence in situ hybridization (FISH) an...
Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
That portion of the stomach remaining after gastric surgery, usually gastrectomy or gastroenterostomy for cancer of the stomach or peptic ulcer. It is a common site of cancer referred to as stump cancer or carcinoma of the gastric stump.
Used as an indicator in titrating iron and for the colorimetric determination of chromium and the detection of cadmium, mercury, magnesium, aldehydes, and emetine.
A proto-oncogene protein and member of the Wnt family of proteins. It is frequently up-regulated in human GASTRIC CANCER and is a tumor marker (TUMOR MARKERS, BIOLOGICAL) of gastric and COLORECTAL CANCER.
A microRNA (abbreviated miRNA) is a small non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals, and some viruses. Key findings: miRNA is involved in the normal functioning of eukaryotic cells, so has dysregulation...
An assay is an analytic procedure for qualitatively assessing or quantitatively measuring the presence or amount or the functional activity of a target entity. This can be a drug or biochemical substance or a cell in an organism or organic sample. ...