Radiation dose efficiency of multi-energy CT for dual-contrast imaging.

07:00 EST 8th November 2019 | BioPortfolio

Summary of "Radiation dose efficiency of multi-energy CT for dual-contrast imaging."

Compared to traditional multi-scan single-energy CT (SECT), one potential advantage of single-scan multi-energy CT (MECT) proposed for simultaneous imaging of multiple contrast agents is the radiation dose reduction. This phantom study aims to rigorously evaluate whether the radiation dose can truly be reduced in a single-scan MECT protocol (MECT_1s) in biphasic liver imaging with iodine and gadolinium, and small bowel imaging with iodine and bismuth, compared to traditional two-scan SECT protocols (SECT_2s). For MECT_1s, mixed iodine/gadolinium samples were prepared corresponding to late arterial/portal-venous phase for biphasic liver imaging. Mixed iodine/bismuth samples were prepared representing the arterial/enteric enhancement for small bowel imaging. For SECT_2s, separate contrast samples were prepared to mimic separate scans in arterial/venous phase and arterial/enteric enhancement. Samples were placed in a 35-cm wide water phantom and scanned by a research whole-body photon-counting-detector-CT (PCD-CT) system ("chess" mode). MECT images were acquired with optimized kV/threshold settings for each imaging task, and SECT images were acquired at 120 kV. Total CTDIvol was matched for the two protocols. Image-based three-material decomposition was employed in MECT_1s to determine the basis material concentration values, which were converted to CT numbers at 120 kV (i.e., virtual SECT images) to compare with the SECT images directly acquired with SECT_2s. The noise difference between the SECT and the virtual SECT images was compared to evaluate the dose efficiency of MECT_1s. Compared to SECT_2s, MECT_1s was not dose efficient for both imaging tasks. The amount of noise increase is highly task dependent, with noise increased by 203%/278% and 110%/82% in virtual SECT images for iodine/gadolinium and iodine/bismuth quantifications, respectively, corresponding to dose increase by 819%/1328% and 340%/230% in MECT_1s to achieve the same image noise level. MECT with the current PCD-CT technique requires higher radiation dose than SECT to achieve the same image quality.


Journal Details

This article was published in the following journal.

Name: Physics in medicine and biology
ISSN: 1361-6560


DeepDyve research library

PubMed Articles [28041 Associated PubMed Articles listed on BioPortfolio]

Dual-Source Dual-Energy CT in Submandibular Sialolithiasis: Reliability and Radiation Burden.

This study aims to compare the diagnostic accuracy of virtual unenhanced CT images derived from dual-source dual-energy contrast-enhanced CT with that of standard unenhanced CT images for evaluation o...

Dual-energy CT for routine imaging of the abdomen and pelvis: radiation dose and image quality.

To assess the radiation dose and image quality of routine dual energy CT (DECT) of the abdomen and pelvis performed in the emergency department setting, compared with single energy CT (SECT).

Feasibility of Multi-Contrast Imaging on Dual-Source Photon Counting Detector (PCD) CT: An Initial Phantom Study.

Photon-counting-detector (PCD)-CT allows separation of multiple, simultaneously-imaged contrast agents, such as iodine (I), gadolinium (Gd), and bismuth (Bi). However, PCDs suffer from several technic...

Coronary CT angiography by modifying tube voltage and contrast medium concentration: Evaluation of image quality and radiation dose.

Currently, there is an increasing interest in noninvasive imaging of cardiovascular system such as computed tomography coronary angiography (CCTA). The risks of radiation-induced cancer and contrast-i...

Dual-source photon counting detector CT with a tin filter: a phantom study on iodine quantification performance.

Photon counting detectors (PCD) can provide spectral information to enable iodine quantification through multi-energy imaging but performance is limited by current PCD technology. The purpose of this ...

Clinical Trials [20638 Associated Clinical Trials listed on BioPortfolio]

Evaluation of Diagnostic Accuracy of Contrast Enhanced Dual Energy Mammography Imaging in Comparison to CE-MRI

Clinical study to evaluate diagnostic accuracy of low dose contrast enhanced dual energy mammography imaging (CEDEM+PRIME) in comparison with CE-MRI The primary objective of this clinical ...

Study of Dual-energy (DE) Contrast-enhanced (CE) Digital Mammography

This is a feasibility study to evaluate dual-energy (DE) contrast-enhanced (CE) digital mammography to detect breast cancer in patients with increased breast density (BI-RADS category c or...

Comparison of Three Methods for Early Detection of Breast Cancer

Subjects with suspicious breast lesion (BIRADS category 4/5) who are scheduled to undergo biopsy will be recruited to undergo imaging evaluation with Contrast Enhanced Dual Energy Mammogra...

Dual Energy CT vs Standard Triple Phase CT-A Randomised Control Trial

The purpose of the Study is to compare the diagnostic efficacy and radiation dose of Split Bolus Dual energy CT with Standard multiphase CECT in evaluation of urological diseases of upper ...

Utility of Perfusion MRI to Detect Radiation Necrosis in Patients With Brain Metastases

This trial studies how well dynamic susceptibility contrast-magnetic resonance imaging (MRI) works in determining radiation necrosis and tumor progression in participants with cancer that ...

Medical and Biotech [MESH] Definitions

The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).

Administration of the total dose of radiation (RADIATION DOSAGE) in parts, at timed intervals.

The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.

A treatment schedule in which the total dose of radiation is divided into large doses.

Quick Search

DeepDyve research library

Relevant Topic

Hepatology is the study of liver, gallbladder, biliary tree, and pancreas, and diseases associated with them. This includes viral hepatitis, alcohol damage, cirrhosis and cancer. As modern lifestyles change, with alcoholism and cancer becoming more promi...

Searches Linking to this Article