Track topics on Twitter Track topics that are important to you
Heart failure (HF) may arise from alterations in metabolic, structural, and signaling pathways, but its genetic architecture is incompletely understood. To elucidate potential genetic contributors to cardiac remodeling and HF, we integrated genome-wide single nucleotide polymorphisms (SNPs), gene expression, and DNA methylation using a transomics analytical approach. We used robust rank aggregation (where the position of a certain gene in a rank order list [based on statistical significance level] is tested against a randomly shuffled rank order list) to derive an integrative trans-omic score for each annotated gene associated with a HF trait. We evaluated up to 8372 Framingham Heart Study participants (54% women, mean age 55±17 years). Of these, 62 (0.7%) and 35 (0.4%) had prevalent HF with reduced and preserved left ventricular (LV) ejection fraction (HFrEF and HFpEF), respectively. During a mean follow-up of 8.5 years (min-max 0.005-18.6 years), 223 (2.7%) and 234 (2.8%) individuals developed incident HFrEF and HFpEF, respectively. Top genes included (matrix metalloprotease 20) and (promotes actin assembly at intercellular junctions) for LV systolic function; (receptor for ) and (complement C5) for LV remodelling; (expressed during myogenic differentiation) and (cytoskeletal protein) for diastolic function; and (involved in regulation of actin cytoskeleton) for prevalent HFrEF; and for incident HFrEF; and for prevalent HFpEF; and (close to the enzyme) and (close to , the riboflavin transporter) for incident HFpEF. We tested the HF-related top SNPs in the UK biobank, where in (MAF 0.023, odds ratio 0.83, p=0.002) remained statistically significant upon Bonferroni-correction. Our integrative transomics approach offers insights into potential molecular and genetic contributors to HF and its precursors. Although several of our candidate genes have been implicated in HF in animal models, independent replication is warranted.
This article was published in the following journal.
Name: Circulation. Genomic and precision medicine
An integrative multi-omics analysis approach that combines multiple types of omics data including genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiomics has become increasi...
Genome-wide multi-omics profiling of complex diseases provides valuable resources and opportunities to discover associations between various measures of genes and diseases. Currently, a pressing chall...
Several studies have found that obesity is associated with atopic dermatitis (AD); however, the mechanisms underlying the association are largely unknown. This study aims to assess the association of ...
In previous study, we performed next-gene sequencing to investigate the differentially expressed transcripts of bovine follicular granulosa cells (GCs) at dominant follicle (DF) and subordinate follic...
Maize is a critically important staple crop in the whole world, which has contributed to both economic security and food in planting areas. The main target for researchers and breeding is the improvem...
This study aims to analyze the multi-omics results between eutopic endometrium, adenomyosis and endometriosis of patients diagnosed of adenomyosis with and without endometriosis. The multi...
This study aims to analyze the multi-omics results between epithelial ovarian cancer (EOC) patient with different FIGO stages and pathological subtypes. The multi-omics profiles include wh...
This study aims to analyze the multi-omics results between uterine cervical adenocarcinoma patients with and without human papillomavirus (HPV) infections. The multi-omics profiles include...
Background Genetic factors play a major role in intellectual disability (ID) but the underlying cause is not determined in many cases. This proposal is the continuation of the previous in...
This study aimed to explore underlying mechanisms of individual differences in drugs for coronary heart disease treatment and its association with adverse consequences. It will enroll appr...
An integrated professional approach to screening, evaluation, control, and reduction of abnormal WEIGHT GAIN.
An integrated nano-scale approach to MEDICINE which involves concurrent diagnosis, drug delivery, therapy, and monitoring of therapeutic response.
A plasmid whose presence in the cell, either extrachromosomal or integrated into the BACTERIAL CHROMOSOME, determines the "sex" of the bacterium, host chromosome mobilization, transfer via conjugation (CONJUGATION, GENETIC) of genetic material, and the formation of SEX PILI.
A concept, developed in 1983 under the aegis of and supported by the National Library of Medicine under the name of Integrated Academic Information Management Systems, to provide professionals in academic health sciences centers and health sciences institutions with convenient access to an integrated and comprehensive network of knowledge. It addresses a wide cross-section of users from administrators and faculty to students and clinicians and has applications to planning, clinical and managerial decision-making, teaching, and research. It provides access to various types of clinical, management, educational, etc., databases, as well as to research and bibliographic databases. In August 1992 the name was changed from Integrated Academic Information Management Systems to Integrated Advanced Information Management Systems to reflect use beyond the academic milieu.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Cardiology is a specialty of internal medicine. Cardiac electrophysiology : Study of the electrical properties and conduction diseases of the heart. Echocardiography : The use of ultrasound to study the mechanical function/physics of the h...
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...