Htra1 is a Novel Transcriptional Target of RUNX2 That Promotes Osteogenic Differentiation.

07:00 EST 1st January 2019 | BioPortfolio

Summary of "Htra1 is a Novel Transcriptional Target of RUNX2 That Promotes Osteogenic Differentiation."

Runt-related transcription factor 2 (Runx2) is a master regulator of osteogenic differentiation, but most of the direct downstream targets of RUNX2 during osteogenesis are unknown. Likewise, High-temperature requirement factor A1 (HTRA1) is a serine protease expressed in bone, yet the role of Htra1 during osteoblast differentiation remains elusive. We investigated the role of Htra1 in osteogenic differentiation and the transcriptional regulation of Htra1 by RUNX2 in primary mouse mesenchymal progenitor cells.


Journal Details

This article was published in the following journal.

Name: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
ISSN: 1421-9778
Pages: 832-850


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