Topics

Evaluating sample stability in the clinical laboratory with the help of linear and non-linear regression analysis.

08:00 EDT 9th August 2019 | BioPortfolio

Summary of "Evaluating sample stability in the clinical laboratory with the help of linear and non-linear regression analysis."

As it is common practice for laboratories to store patient samples for a predefined period, allowing clinicians to request additional tests on previously collected samples, knowledge about sample stability is indispensable for the laboratorian. A common approach to estimating the maximum storage time is to use a discrete study design, measuring the analyte of interest at various time-points and then checking for significant differences with the help of a statistical test, such as Student's t-test, Wilcoxon's test or an analysis of variance (ANOVA) test. Because only discrete time intervals are considered, stability data can just be approximated. Alternatively, a continuous study design, as described by the Clinical and Laboratory Standards Institute (CLSI) for performing stability experiments for in vitro diagnostic reagents, can also be adopted by the clinical laboratory to evaluate the stability of biological samples. The major advantage of this approach is that it allows laboratories to define individual stability limits for different medical situations and offers more flexibility when choosing time-points for measurements. The intent of this paper is to demonstrate the evaluation of sample stability in the clinical laboratory with a continuous study design implemented with linear or non-linear regression analysis. Appropriate statistical modeling and acceptance criteria are presented, stability functions are described briefly, and checking the overall validity of the results is discussed.

Affiliation

Journal Details

This article was published in the following journal.

Name: Clinical chemistry and laboratory medicine
ISSN: 1437-4331
Pages:

Links

DeepDyve research library

PubMed Articles [32807 Associated PubMed Articles listed on BioPortfolio]

Evaluating sample stability in the clinical laboratory with the help of linear and non-linear regression analysis.

As it is common practice for laboratories to store patient samples for a pre-defined period, allowing clinicians to request additional tests on previously collected samples, knowledge about sample sta...

Triethylamine improves MS signals stability of diluted oligonucleotides caused by sample containers.

The effect of sample containers made of different materials on the MS-based analysis of oligonucleotides remains unknown. Here, we evaluated five types of sample containers on the MS signal stability ...

"On Vivo" and Wearable Clinical Laboratory Testing Devices for Emergency and Critical Care Laboratory Testing.

Point-of-care testing (POCT) devices are designed for clinical laboratory testing at the bedside or near the patient and can significantly reduce the turnaround time for laboratory test results. The n...

Comparative analysis of calculating sigma metrics by a trueness verification proficiency testing-based approach and an internal quality control data inter-laboratory comparison-based approach.

Two methods were compared for evaluating the sigma metrics of clinical biochemistry tests using two different allowable total error (TEa) specifications.

Serum or plasma? An old question looking for new answers.

Serum or plasma? An old question looking for new answers. There is a continual debate on what type of sample a clinical laboratory should use. While serum is still considered the gold standard and rem...

Clinical Trials [10555 Associated Clinical Trials listed on BioPortfolio]

Molecular Analysis of Microphthalmia/Anophthalmia

This study will try to learn more about the genetic cause and symptoms of microphthalmia (small eyes) or anophthalmia (absence of one or both eyes). Patients with microphthalmia or anopht...

Assessment of Stability of Mail-in Capillary Hemoglobin A1c Test Kit

The purpose of this study is to determine the stability of capillary HBA1c blood samples collected by the participant with this kit and mailed to the laboratory at Children's Mercy Hospita...

CMC I Stability Intraoperative

The goal of the current study is to objectively measure intraoperative the initial thumb stability after trapezium removal when performing trapeziectomy, alone or in combination with suspe...

Retrospective Study of the Linear™ Hip

The purpose of this study is to evaluate the use and efficacy of the Encore Linear™ Hip System in a group of 200 patients for whom data has already been collected.

Liner Ablation Using Contact-force in Atrial Fibrillation

Linear ablation is frequently used in the procedure for persistent atrial fibrillation. However, it has a limitation because of technical difficulty. Incomplete block is common and an impo...

Medical and Biotech [MESH] Definitions

Organized services provided by MEDICAL LABORATORY PERSONNEL for the purpose of carrying out CLINICAL LABORATORY TECHNIQUES used for the diagnosis, treatment, and prevention of disease.

The specialty related to the performance of techniques in clinical pathology such as those in hematology, microbiology, and other general clinical laboratory applications.

Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative and clinical activities associated with the provision and utilization of clinical laboratory services.

Laboratory tests for evaluating the individual's clotting mechanism.

A subspecialty of pathology applied to the solution of clinical problems, especially the use of laboratory methods in clinical diagnosis. (Dorland, 28th ed.)

Quick Search


DeepDyve research library

Relevant Topic

Biological Therapy
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...


Searches Linking to this Article