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There is still lack of a simple, accurate and noninvasive method for rat aortic pulse wave velocity (PWV) measurement, especially the transit distance cannot be accurately measured. Thus we aimed to derive an equation for aortic transit distance as a function of the nose-to-rump length (L), and to test the hypothesis that aortic PWV measured by new equation combined with Doppler ultrasound (the "equation method") may have stronger correlation with invasive measurements than traditional "body surface method". Two hundred male Sprague-Dawley (SD) rats (age ranged 5-24 weeks) were included in Protocol 1 and the aortic transit distances were measured post mortem. In Protocol 2, heart-femoral PWV and carotid-femoral PWV were measured by "equation method" (hfPWV, cfPWV), and also by traditional "body surface method" (hfPWV, cfPWV) in another 30 young and 28 old rats. Then these measurements were validated against invasively measured hfPWV, cfPWV from the same animal. Protocol 1 showed that the heart-femoral transit distance could be calculated by 0.6086×L-1.6523, the carotid-femoral transit distance by 0.4614×L+1.8335. In Protocol 2, in young rats, the Pearson r between hfPWV, cfPWV, hfPWV, cfPWV and their corresponding invasive measurement were 0.8962, 0.8509, 0.8387, 0.7828, respectively (all <0.0001). In old group, the results were 0.8718, 0.7999, 0.8330, 0.7112, respectively (all <0.0001). The hfPWV and cfPWV showed better agreement with hfPWV and cfPWV, and lower intra- and inter-observer variability compared with hfPWV and cfPWV in both groups. These findings demonstrate that this novel methodology provides a simple and reliable method for rat noninvasive aortic PWV measurement.
This article was published in the following journal.
Name: American journal of physiology. Heart and circulatory physiology
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