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Analysis of factors associated with recovery of the serum pepsinogen ratio after eradication: a long-term follow-up study in Korea.

07:00 EST 8th November 2019 | BioPortfolio

Summary of "Analysis of factors associated with recovery of the serum pepsinogen ratio after eradication: a long-term follow-up study in Korea."

Serum levels of pepsinogen (PG) are related to -induced inflammation of the gastric mucosa. This study aimed to examine the influence of eradication on serum PG, analyze its associated factors, and evaluate the long-term outcomes.-positive patients who underwent gastroscopy and serum PG measurement were enrolled in a single academic hospital. After eradication, the measurement of serum PG level was performed. Recovery of serum PG I/II ratio was defined as a PG I/II ratio after eradication of >3.0 in patients with a PG I/II ratio ≤ 3.0 before eradication. Follow-up involved serum PG measurement and gastroscopy with a rapid urease test annually. In all, 327 patients were eligible for study inclusion. Compared to those before eradication, serum PG I (74.9 vs. 44.3 ng/mL,  < .001) and PG II (25.4 vs. 9.1 ng/mL,  < .001) levels significantly decreased after successful eradication. In addition, there was a significant increase in serum PG I/II ratio after eradication (3.07 vs. 4.98,  < .001). In multivariate analyses, the following were independently associated with failed recovery of serum PG I/II ratio despite successful eradication: age ≥ 60 years (odds ratio [OR] = 0.231, 95% confidence interval [CI] = 0.084-0.629,  = .004) and severe gastric atrophy (OR = 0.156, 95% CI = 0.055-0.440,  < .001). Recovery of serum PG I/II ratio after eradication may be achieved in -infected patients aged <60 years without severe gastric atrophy.

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This article was published in the following journal.

Name: Scandinavian journal of gastroenterology
ISSN: 1502-7708
Pages: 1-9

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