Pd(0)-Catalyzed Cyclizative Carboboration of -Iodo-1,6-diene ( = 1 or 2): Access to Structurally Complex Allylboronates and Alkylboronates.

07:00 EST 8th November 2019 | BioPortfolio

Summary of "Pd(0)-Catalyzed Cyclizative Carboboration of -Iodo-1,6-diene ( = 1 or 2): Access to Structurally Complex Allylboronates and Alkylboronates."

A Pd(0)-catalyzed cyclizative carboboration reaction of -iodo-1,6-diene ( = 1, 2) with Bpin has been developed. When 1-iodo-1,6-diene was employed as the substrate, a process of intramolecular 6,6-alkenylboration was achieved to deliver 6-membered cyclic allylborate. On the other hand, 2-iodo-1,6-diene was found to proceed via 2-cyclopropanation/1-boration, thus affording a (bicyclo[3.1.0]hexan-1-ylmethyl)borate product.


Journal Details

This article was published in the following journal.

Name: Organic letters
ISSN: 1523-7052


DeepDyve research library

PubMed Articles [5238 Associated PubMed Articles listed on BioPortfolio]

Rhenium-Catalyzed Cyclization via 1,2-Iodine and 1,5-Hydrogen Migration for the Synthesis of 2-Iodo-1-indenes.

A rhenium complex catalyzed the formation of 2-iodo-1-indene derivatives through iodine and hydrogen migration of 3-iodopropargyl ethers. The reaction proceeded via generation of 1-iodoalkenylrhenium ...

Ring closing metathesis (RCM) approach to the synthesis of conduramine B-2, ent-conduramine F-2, aminocyclopentitol and trihydroxyazepane.

The syntheses of conduramine B-2, ent-conduramine F-2, aminocyclopentitol and trihydroxyazepane were accomplished from a common precursor, through a divergent approach using ring closing metathesis (R...

Access to Enantioenriched Spiro-ε-Lactam Oxindoles via an N-Heterocyclic Carbene-Catalyzed 4+3 Annulation of Flexible Oxotryptamines with Enals.

Oxotryptamines were firstly used as flexible four-atom synthons in an NHC-catalyzed formal [4+3] annulation, providing a novel enantioselective method to access structurally diverse spiro-ε-lactam ox...

Glycopeptides by Linch-Pin C-H Activations for Peptide-Carbohydrate Conjugation by Manganese(I)-Catalysis.

Late-stage C-H glycosylations of structurally complex amino acids and peptides were accomplished by means of racemization-free manganese(I)-catalyzed C-H activation. Thus, glycosylative modifications ...

Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction.

Bicyclic ether scaffolds are found in a variety of natural products and are of interest in probe and drug discovery. A palladium-catalyzed cascade reaction has been developed to provide efficient acce...

Clinical Trials [2407 Associated Clinical Trials listed on BioPortfolio]

4'-Iodo-4'-Deoxydoxorubicin in Treating Patients With Primary Systemic Amyloidosis

RATIONALE: 4'-Iodo-4'-deoxydoxorubicin may improve organ dysfunction and ease symptoms caused by primary systemic amyloidosis. PURPOSE: Phase II trial to study the effectiveness of 4'-iod...

131I-IPA + XRT as Treatment for Patients With Glioblastoma Multiforme

A multi-centre, open-label, single-arm, dose-finding phase I/II study to evaluate safety, tolerability, dosing schedule, and preliminary efficacy of carrier-added 4-L-[131I]iodo-phenylalan...

Complex Large-bore Radial Percutaneous Coronary Intervention (PCI) Trial

The COLOR trial is a Multicenter Randomized trial. Patients are eligible for study participation when PCI is indicated for complex coronary lesions. If patients comply with inclusion and e...

A Study to Evaluate the Use of Stavudine (d4T) to Treat AIDS Dementia Complex

The purpose of this study is to see if adding stavudine (d4T) to anti-HIV drug regimens (with or without zidovudine, ZDV) can improve symptoms of AIDS Dementia Complex (ADC, problems invol...

Neurodevelopment in Infants With Complex Congenital Heart Defects

The primary goal of this study is to systematically describe early neurodevelopment using a complementary set of observational and neurophysiological measures that may predict cognitive an...

Medical and Biotech [MESH] Definitions

Also called 4-hydroxy-3-iodo-5-nitrophenylacetate. A haptenic determinant that can be radiolabeled and used as salts and derivatives for investigations of immunogenic specificity studies.

An Act that amends Title XVIII of the Social Security Act to repeal the Medicare sustainable growth rate, that strengthens Medicare access by improving physician payments, and that reauthorizes the Children's Health Insurance Program (CHIP).

Agreement in which author(s) and copyright holder(s) grant(s) to all users a free, irrevocable, worldwide, perpetual right of access to, and a license to copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship, as well as the right to make small numbers of printed copies for their personal use. A complete version of the work and all supplemental materials, including a copy of the permission as stated above, in a suitable standard electronic format is deposited immediately upon initial publication in at least one online repository that is supported by an academic institution, scholarly society, government agency, or other well-established organization that seeks to enable open access, unrestricted distribution, interoperability, and long-term archiving. (from Bethesda Statement on Open Access Publishing)

Used in copolymerization reactions, in the Diels-Alder(diene)synthesis, in the preparation of resins, pharmaceuticals and agricultural chemicals. It is a powerful irritant and causes burns.

A highly conserved family of ATPases that facilitate the transport of lipids and cations across the plasma membrane. Structurally, they are elongated ALPHA-HELICES constituting five functionally distinct domains: three cytoplasmic domains A, N, and P which contain the catalytic sites, and two transmembrane domains. The N domain phosphorylates the P-domain at an invariant ASPARTATE residue, which, in turn, is dephosphorylated by the A domain. The phosphorylation and dephosphorylation cycles drive conformational changes in the protein between two states (E1 and E2), which allow the substrate to access the other side of the membrane.

Quick Search

DeepDyve research library

Searches Linking to this Article