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Natural products that target virulence factors in antibiotic resistant Staphylococcus aureus.

07:00 EST 8th November 2019 | BioPortfolio

Summary of "Natural products that target virulence factors in antibiotic resistant Staphylococcus aureus."

The increase in the incidence of antibiotic-resistant Staphylococcus aureus (S. aureus)-associated infections necessitates the urgent development of novel therapeutic strategies and antibacterial drugs. Anti-virulence strategy is an especially compelling alternative strategy due to its low selective pressure for the development of drug resistance in bacteria. Plants and microorganisms are not only important food and medicinal resources, but also serve as sources for the discovery of natural products that target bacterial virulence factors. This review discusses the mechanisms of the major virulence factors of S. aureus, including the accessory gene regulator quorum-sensing system, bacterial biofilm formation, α-hemolysin, sortase A, and staphyloxanthin. We also provide an overview of natural products isolated from plants and microorganisms with activity against the major virulence factors of S. aureus and their adjuvant effects on existing antibiotics to overcome antibiotic-resistant S. aureus. Finally, the limitations of and solutions to these anti-virulence compounds are discussed, which will help in the development of novel antibacterial drugs against antibiotic-resistant S. aureus.

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This article was published in the following journal.

Name: Journal of agricultural and food chemistry
ISSN: 1520-5118
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