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Total Chemical Synthesis of All SUMO-2/3 Dimer Combinations.

07:00 EST 8th November 2019 | BioPortfolio

Summary of "Total Chemical Synthesis of All SUMO-2/3 Dimer Combinations."

One hallmark of protein chemical synthesis is its capacity to access proteins that living systems can hardly produce. This is typically the case for proteins harboring post-translational modifications such as ubiquitin or ubiquitin-like modifiers. Various methods have been developed for accessing polyubiquitin conjugates by semi- or total synthesis. Comparatively, the preparation of small-ubiquitin-like modifier (SUMO) conjugates, and more particularly of polySUMO scaffolds, is much less developed. We describe hereinafter a synthetic strategy for accessing all SUMO-2/3 dimer combinations.

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Name: Bioconjugate chemistry
ISSN: 1520-4812
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