Engineering Biodegradable Multifunctional Antibacterial Bioactive Nanosystem for Enhancing Tumor Photothermo-Chemotherapy and Bone Regeneration.

07:00 EST 8th November 2019 | BioPortfolio

Summary of "Engineering Biodegradable Multifunctional Antibacterial Bioactive Nanosystem for Enhancing Tumor Photothermo-Chemotherapy and Bone Regeneration."

The simultaneous therapy of tumor and bone defects resulted from tumor surgery is still a challenge in the clinical orthopedics. Few nanomaterials systems simultaneously possess multifunctional capacities including biodegradability, treating tumor and enhancing bone regeneration. Herein, we designed a biodegradable monodispersed bioactive glass nanoparticles (BGN) platform with multifunctional properties for enhanced colon cancer photothermo-chemotherapy and bone repair. The mussel-inspired surface assembling with BGN was established as a stable NIR-excited photothermal nanoplatform (BGN@PDA) for ablating tumor. BGN@PDA shows an ultrahigh anticancer drug (DOX) loading with on-demand (pH/NIR-responsive) drug releasing behavior and antibacterial activity for enhanced tumor chemotherapy (BGN@PDA-DOX). The growth of colon cancer cells (Hct116 cells) and cervical cancer cells (Hela cells) was significantly inhibited in vitro and superior local anti-cancer efficacy could be achieved by synergic chemo-photothermal-therapy in vivo. BGN@PDA underwent a gradual degradation in vivo during 60 days and showed negligible side toxicity effects. Meanwhile, BGN@PDA could positively induce the osteogenesis of osteoblasts in vitro and possess excellent in vivo bone repair ability in rat cranial defects. This work presents a distinctive strategy to design bioactive multifunctional nanoplatform for treating tumor disease-resulted bone tissue regeneration.


Journal Details

This article was published in the following journal.

Name: ACS nano
ISSN: 1936-086X


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