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The simultaneous therapy of tumor and bone defects resulted from tumor surgery is still a challenge in the clinical orthopedics. Few nanomaterials systems simultaneously possess multifunctional capacities including biodegradability, treating tumor and enhancing bone regeneration. Herein, we designed a biodegradable monodispersed bioactive glass nanoparticles (BGN) platform with multifunctional properties for enhanced colon cancer photothermo-chemotherapy and bone repair. The mussel-inspired surface assembling with BGN was established as a stable NIR-excited photothermal nanoplatform (BGN@PDA) for ablating tumor. BGN@PDA shows an ultrahigh anticancer drug (DOX) loading with on-demand (pH/NIR-responsive) drug releasing behavior and antibacterial activity for enhanced tumor chemotherapy (BGN@PDA-DOX). The growth of colon cancer cells (Hct116 cells) and cervical cancer cells (Hela cells) was significantly inhibited in vitro and superior local anti-cancer efficacy could be achieved by synergic chemo-photothermal-therapy in vivo. BGN@PDA underwent a gradual degradation in vivo during 60 days and showed negligible side toxicity effects. Meanwhile, BGN@PDA could positively induce the osteogenesis of osteoblasts in vitro and possess excellent in vivo bone repair ability in rat cranial defects. This work presents a distinctive strategy to design bioactive multifunctional nanoplatform for treating tumor disease-resulted bone tissue regeneration.
This article was published in the following journal.
Name: ACS nano
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Methods and techniques used to modify or select cells and develop conditions for growing cells for biosynthetic production of molecules (METABOLIC ENGINEERING), for generation of tissue structures and organs in vitro (TISSUE ENGINEERING), or for other BIOENGINEERING research objectives.
Application of principles and practices of engineering science to the transformation, design, and manufacture of substances on an industrial scale.
A branch of engineering concerned with the design, construction, and maintenance of environmental facilities conducive to public health, such as water supply and waste disposal.
Application of principles and practices of engineering science to biomedical research and health care.
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