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Regulation of Immune Activation by Optical Control of TLR1/2 Dimerization.

07:00 EST 8th November 2019 | BioPortfolio

Summary of "Regulation of Immune Activation by Optical Control of TLR1/2 Dimerization."

The activation of toll like receptors (TLRs) plays important roles in the immune response. The ability to control the activities of TLRs could be used as a switch for immune response. Herein, we rationally designed and synthesized a photoswitchable Pam3CSK4 derivative (P10) to control the activation of TLR1/2. The ground state trans-P10 could stimulate and activate antigen-presenting cells (APCs) through promoting the TLR1/2 dimerization. However, the cis-P10, derived from UV irradiation of trans-P10, reduced the activities of APCs by impeding the TLR1/2 dimerization. In the absence of UV radiation, the cis-P10 slowly returned to its ground trans state, restoring the activities of the APCs stimulating. Our results indicated that the optical control of TLR1/2 dimerization mediated by the photoswitchable P10 holds potential to regulate the immune activation and inflammation.

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This article was published in the following journal.

Name: Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
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