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The activation of toll like receptors (TLRs) plays important roles in the immune response. The ability to control the activities of TLRs could be used as a switch for immune response. Herein, we rationally designed and synthesized a photoswitchable Pam3CSK4 derivative (P10) to control the activation of TLR1/2. The ground state trans-P10 could stimulate and activate antigen-presenting cells (APCs) through promoting the TLR1/2 dimerization. However, the cis-P10, derived from UV irradiation of trans-P10, reduced the activities of APCs by impeding the TLR1/2 dimerization. In the absence of UV radiation, the cis-P10 slowly returned to its ground trans state, restoring the activities of the APCs stimulating. Our results indicated that the optical control of TLR1/2 dimerization mediated by the photoswitchable P10 holds potential to regulate the immune activation and inflammation.
This article was published in the following journal.
Name: Chembiochem : a European journal of chemical biology
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A family of basic helix-loop-helix transcription factors that control expression of a variety of GENES involved in CELL CYCLE regulation. E2F transcription factors typically form heterodimeric complexes with TRANSCRIPTION FACTOR DP1 or transcription factor DP2, and they have N-terminal DNA binding and dimerization domains. E2F transcription factors can act as mediators of transcriptional repression or transcriptional activation.
Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.
The use of light interaction (scattering, absorption, and fluorescence) with biological tissue to obtain morphologically based information. It includes measuring inherent tissue optical properties such as scattering, absorption, and autofluorescence; or optical properties of exogenous targeted fluorescent molecular probes such as those used in optical MOLECULAR IMAGING, or nontargeted optical CONTRAST AGENTS.
A signal transducing adaptor protein that contains a single SH2 DOMAIN and is essential for the regulation of SLAM FAMILY RECEPTORS in the immune response. Mutations in the SLAM-associated protein gene have been identified in cases of X-LINKED LYMPHOPROLIFERATIVE DISEASE.
The use of biological mechanisms, usually involving living organisms such as bacteria, for the reduction or regulation of the population of noxious, destructive, or dangerous pests. Environmental concerns have focused attention on natural forms of disease control as potentially safe and effective alternatives to chemical pesticides. This has led to increased efforts to develop control strategies that rely on natural predators and parasites or that involve genetically engineered microbial pest control agents.