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The progression of ischemic cerebral edema (CE) is closely related to the level of cerebral blood perfusion (CBP) and affects each other. Simultaneous detection of CBP and CE is helpful in understanding the mechanisms of ischemic cerebral edema development. In this article, a wide field of view (FOV) SS-OCT system was used to detect CE status and CBP levels simultaneously in middle cerebral artery occlusion (MCAO) rats. Images reflecting these two physiological states can be reconstructed with only one C-scan. We quantify these two physiological states into 4 parameters, which contain two vascular parameters (vascular displacement distance and vascular perfusion density) and two edema parameters (optical attenuation coefficient and edema area). The association between the two vascular parameters and the two edema parameters were analyzed. The results show that there is a strong linear relationship between blood flow parameters and edema parameters. This work provides a new option for CE in vivo detection, and is very likely to play an important role in the development of relevant drugs or in selection of treatment options. This article is protected by copyright. All rights reserved.
This article was published in the following journal.
Name: Journal of biophotonics
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