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ConSurf-DB: An accessible repository for the evolutionary conservation patterns of the majority of PDB proteins.

07:00 EST 8th November 2019 | BioPortfolio

Summary of "ConSurf-DB: An accessible repository for the evolutionary conservation patterns of the majority of PDB proteins."

Patterns observed by examining the evolutionary relationships among proteins of common origin can reveal the structural and functional importance of specific residue positions. In particular, amino acids that are highly conserved (i.e., their positions evolve at a slower rate than other positions) are particularly likely to be of biological importance, for example, for ligand binding. ConSurf is a bioinformatics tool for accurately estimating the evolutionary rate of each position in a protein family. Here we introduce a new release of ConSurf-DB, a database of pre-calculated ConSurf evolutionary conservation profiles, for proteins of known structure. ConSurf-DB provides high-accuracy estimates of the evolutionary rates of the amino acids in each protein. A reliable estimate of a query protein's evolutionary rates depends on having a sufficiently large number of effective homologues (i.e., non-redundant yet sufficiently similar). With current sequence data, ConSurf-DB covers 82% of the PDB proteins. It will be updated on a regular basis to ensure that coverage remains high - and that it might even increase. Much effort was dedicated to improving the user experience. The repository is available at https://consurfdb.tau.ac.il/. This article is protected by copyright. All rights reserved.

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Name: Protein science : a publication of the Protein Society
ISSN: 1469-896X
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