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Multi-Drug Resistant Gastrointestinal Stromal Tumor with Multiple Metastasis to the Skin and Subcutaneous Soft Tissue: A Case Report and Review of Literature.

07:00 EST 8th November 2019 | BioPortfolio

Summary of "Multi-Drug Resistant Gastrointestinal Stromal Tumor with Multiple Metastasis to the Skin and Subcutaneous Soft Tissue: A Case Report and Review of Literature."

Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms which account for less than 1% of all gastrointestinal malignancies. Of all the extra-abdominal metastases of GIST, superficial soft tissue metastases are the most rare. Previous reports have found success with sunitinib in imatinib-resistant GIST, but we report a certain wild-type KIT mutation GIST with cutaneous and subcutaneous metastasis that was unresponsive to multiple tyrosine kinase inhibitor treatments. This case illustrates that knowing the specific type of KIT mutations may uncover resistance of certain GIST's to tyrosine-kinase inhibitors, necessitating more targeted and alternative therapy. This article is protected by copyright. All rights reserved.

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Name: Journal of cutaneous pathology
ISSN: 1600-0560
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Medical and Biotech [MESH] Definitions

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