Biological activity of weekly ONC201 in adult recurrent glioblastoma patients.

07:00 EST 8th November 2019 | BioPortfolio

Summary of "Biological activity of weekly ONC201 in adult recurrent glioblastoma patients."

ONC201 is a dopamine receptor D2 (DRD2) antagonist that penetrates the blood-brain barrier. ONC201 efficacy has been shown in glioblastoma animal models and is inversely correlated with dopamine receptor DRD5 expression. ONC201 is well tolerated in adult recurrent glioblastoma patients with dosing every 3 weeks and has achieved an objective radiographic response in a patient harboring the H3 K27M mutation.


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This article was published in the following journal.

Name: Neuro-oncology
ISSN: 1523-5866


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Medical and Biotech [MESH] Definitions

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A blood protein (NSILA) which mimics the biological activity of insulin in serum, but is not suppressed by insulin antibodies. During acid-ethanol extraction of Cohn fraction III, 10% of the activity is found in the supernatant (NSILA-S) and the remaining activity in the precipitate (NSILA-P). The latter is a large molecular compound, much less stable than the soluble fraction. NSILA-S is a more potent growth factor than insulin and exhibits sulfation activity.

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