Track topics on Twitter Track topics that are important to you
. is responsible for several types of oral and systemic infections. In light of emerging resistance to antifungals, studies have demonstrated the antifungal effect of lactoferrin (LF), which is part of the innate immune system, has anticandidal activities.. (2×10 c.f.u. ml) were incubated either with PBS or human LF (hLF) (100 µg ml) at 37 °C for 24 h and then RNA was isolated and virulence factors analysed. (1×10 c.f.u.) was injected into the tail vein of immunocompromised wild-type and . Then, 24 h later, the I mice received hLF intravenously (100 µg g body weight), while the control group received PBS. Then, 48 h later, the organs were collected, homogenized and c.f.u.s were counted. In addition, the inflammatory mediators of kidneys and the virulence factors of were analysed.. hLF-treated I mice showed significant clearance of in different organ tissues when compared to untreated I mice. The inflammatory cytokines, such as IL-1, IL- TNF- and and iNOS were downregulated in hLF-treated I mice when compared to untreated I mice. Whereas, IL-10 and IL-17A were upregulated at 72 h post infection when compared to C mice. Histological analysis also revealed a significant decrease in the size and number of infectious foci in the hLF-treated groups. hLF treatment significantly downregulated several virulence factors of both and .. We concluded that hLF-treated mice can reduce the severity of -induced systemic infection.
This article was published in the following journal.
Name: Journal of medical microbiology
Lactoferrin is a non-heme iron-binding glycoprotein with multiple health-beneficial functions including antimicrobial, antioxidant, anticarcinogenic, and immunomodulatory effects. There is emerging ev...
Cutaneous candidiasis is a common skin disease and several treatments have been investigated within the last fifty years. Yet, systematic reviews are lacking, and evidence- based topical as well as sy...
Candida albicans is the most important fungal pathogen that causes infections in humans. Biofilms are hard-to-treat structures due to their high antifungal resistance. Saliva is a fluid that contains ...
Necrotizing enterocolitis (NEC) is a devastating intestinal illness in premature infants characterized by severe intestinal inflammation. Despite medical interventions, NEC mortality remains alarmi...
The oral mucosa is likely to be compromised by acquired systemic disease. There are no data available on the prevalence of oral candidiasis and the species distribution among patients with oral mucosa...
This will be a randomised control trial designed to test the effectiveness of lactoferrin in the management of treatment-induced anemia in patients with hematological malignancies.
Glutamine levels decrease during severe sepsis; this may be associated with increased mortality. The investigators tested the effects of glutamine supplementation on systemic inflammation ...
The aim of the study is to evaluate the effect of vaginal lactoferrin administration on amniotic fluid PGE2 level and MMP-TIMP system in women undergoing genetic amniocentesis. Two groups ...
The primary purpose of this study is to evaluate the pharmacokinetic profile of micafungin administered to neonates suffering from systemic candidiasis. This study will also evaluate the p...
Oral lactoferrin versus Placebo will be given to preterm neonates
Traumatic or experimentally induced separation of the head from the body in an animal or human.
Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA.
A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA.
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...
Cytokine Tumour Necrosis Factor (TNF)
TNF is a compound that is classified as a cytokine which plays a central role in the cellular mechanisms of apoptosis or cell death. However, there are a number of different kinds of TNF, just under twenty, but the family of molecules have very similar a...
Antiretroviral Therapy Clostridium Difficile Ebola HIV & AIDS Infectious Diseases Influenza Malaria Measles Sepsis Swine Flu Tropical Medicine Tuberculosis Infectious diseases are caused by pathogenic...