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Improvement in Fibromyalgia Symptoms and Skin Biopsy Results in Patients with Fibromyalgia Related Small Fiber Neuropathy.

07:00 EST 6th November 2019 | BioPortfolio

Summary of "Improvement in Fibromyalgia Symptoms and Skin Biopsy Results in Patients with Fibromyalgia Related Small Fiber Neuropathy."

Small fiber neuropathy and fibromyalgia are two conditions that share overlapping features. Although various treatments are available for use in fibromyalgia, the response often remains unsatisfactory. Prior studies have shown that in small fiber neuropathy of autoimmune etiology, intravenous immunoglobulin (IVIg) holds promise as an effective treatment. Herein we report the use of IVIg in 7 patients who have both fibromyalgia and small fiber neuropathy. Skin punch biopsy evaluating the nerve fiber density was performed prior to diagnosis and after 6 months of IVIg therapy in each individual. Patient's symptoms were obtained via a fibromyalgia questionnaire pre- and post- treatment. At the end of 6 months therapy, overall patients reported less fibromyalgia symptoms and skin biopsy demonstrated improvements as well. This retrospective pilot study suggests IVIg is a viable potential therapy in a subset of fibromyalgia patients who have small fiber neuropathy.

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Name: Current rheumatology reviews
ISSN: 1875-6360
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Medical and Biotech [MESH] Definitions

A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)

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Conducting a biopsy procedure with the aid of a MEDICAL IMAGING modality.

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