Whether The Validation Of The Predictive Potential Of Toxicity Models Is Solved Task?

07:00 EST 4th November 2019 | BioPortfolio

Summary of "Whether The Validation Of The Predictive Potential Of Toxicity Models Is Solved Task?"

Different kinds of biological activity are defined by complex biochemical interactions, i.e. are a "mathematical function" not only of the molecular structure but also some unclear addition circumstances, such as physicochemical conditions, interactions via energy and information effects between a substance and organisms, organs, cells. These circumstances lead to great complexity of prediction for biochemical endpoints, since all "details" of corresponding phenomena are practically unavailable for the accurate registration and analysis Objective: Researchers have not possibility to carry out and analyse all possible ways of the biochemical interactions, which define toxicological or therapeutically attractive effects via direct experiment. Consequently, a compromise, i.e the development of predictive models of the above phenomena become necessary.


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This article was published in the following journal.

Name: Current topics in medicinal chemistry
ISSN: 1873-4294


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