Spiro-Lactams as Novel Antimicrobial Agents.

07:00 EST 4th November 2019 | BioPortfolio

Summary of "Spiro-Lactams as Novel Antimicrobial Agents."

To extend our previous studies on spirocyclic-β-lactams with anti-HIV and antiplasmodial properties to new spirocyclic-lactams in order to further explore structure-activity relationships.


Journal Details

This article was published in the following journal.

Name: Current topics in medicinal chemistry
ISSN: 1873-4294


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Medical and Biotech [MESH] Definitions

LACTAMS forming compounds with a ring size of approximately 1-3 dozen atoms.

Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.

Tetracyclic spiro-BENZAZEPINES isolated from the seeds of CEPHALOTAXUS. They are esters of the alkaloid cephalotaxine and may be effective as antineoplastic agents.

The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

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AIDS; Acquired Immune Deficiency Syndrome. HIV; Human Immunodeficiency Virus HIV infection causes AIDS. HIV infection also causes the production of anti-HIV antibodies, which forms the test for HIV in patients. People who have the HIV antibodies are ...

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